CAS: 13631-21-5; 4-Bromo-3-Chlorophenol

相似化合物

1940-28-9 855836-62-3 3964-56-5

上下游产品

3-氯苯酚 3-Chlorophenol 108-43-0

3-氯苯酚置于溶剂黄146,Potassium Bromide体系中,用 水,溶剂黄146 用作溶剂,以81%的收率获得4-溴-3-氯酚
参考文献:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
标题:Kbr 和 Znal-Bro3−-层状双氢氧化物对苯酚进行区域选择性单溴化
摘要:以 Kbr 和 Znal-Bro3--层状双氢氧化物(缩写为 Znal-Bro3--Ldhs)作为溴化试剂,成功开发了苯酚的区域选择性单溴化反应.对位点比较有利,如果对位点被占用,则邻位点优先.该反应具有优异的区域选择性,廉价的溴化试剂,反应条件温和,原子经济性高,底物范围广等特点,为溴代苯酚的合成提供了一种有效的方法.
Doi:10.3390/molecules25040914

专利信息

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.

专利号:US-12358903-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FARAND JULIE; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-11739065-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-9820979-B2
优先权日:2011-07-13
标 题:FXR (NR1H4) binding and activity modulating compounds
发明人：KINZEL OLAF; STEENECK CHRISTOPH; KREMOSER CLAUS
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives

专利号:US-11225473-B2
优先权日:2019-01-15
标题:FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FRICK MORIN MAE; HORSTMAN ELIZABETH M; KAPLAN JOSHUA A; KROPF JEFFREY E; WATKINS WILLIAM J
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.