CAS: 148461-14-7; (S)-2-(2-(Diphenylphosphino)Phenyl)-4-Isopropyl-4,5-Dihydrooxazole

上下游产品

(-)-(S)-2-(2-fluoro-phenyl)-4-isopropyl-4,5-dihydro-oxazole potassium diphenylphosphine chloro-diphenylphosphine (-)-(S)-2-(2-bromo-phenyl)-4-isopropyl-4,5-dihydro-oxazole

2-甲氧基苯甲腈置于potassium Tert-Butylate,Zinc(II) Chloride体系中,用 环己烷,氯苯 用作溶剂,化学反应 159.0H,反应生成二氢二苯磷苯基-4-异丙恶唑
参考文献:苯酚衍生物的膦化反应及其在膦配体发散合成中的应用
标题:苯酚衍生物的膦化反应及其在膦配体发散合成中的应用
摘要:我们描述了通过无金属 C-O 键断裂和 C-P 键形成过程从酚类和膦 (R 2 Ph)合成有机膦化合物的通用和有效方案.这种方法表现出广泛的底物范围和优异的官能团耐受性.通过氰基的各种转化及其在不对称催化中的应用来合成手性配体,证明了该协议的合成效用.
Doi:10.1021/acs.Orglett.1C03227

专利信息

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.