2-甲基异喹啉-1(2H)-酮置于1,3-二溴-1,3,5-三嗪-2,4,6-三酮,三苯基膦体系中,用 Neat (No Solvent) 用作溶剂,化学反应 17.0H,以53%的收率获得1-溴异喹啉 参考文献:Development Of A Facile And Inexpensive Route For The Preparation Of α-Halobenzopyridines From α-Unsubstituted Benzopyridines 标题:Development Of A Facile And Inexpensive Route For The Preparation Of α-Halobenzopyridines From α-Unsubstituted Benzopyridines 摘要:A Facile And Inexpensive Route For The Preparation Of Alpha-Halobenzopyridines From Alpha-Unsubstituted Benzopyridines Via N-Methylbenzopyridin-Alpha-Ones Was Developed. Alpha-Unsubstituted Benzopyridines Were Converted Easily Into The Corresponding N-Methylbenzopyridin-Alpha-Ones,Which Were Halogenated Using Pph3-Tcica Or Pph3-Dbica Without Using Solvent To Give A-Halobenzopyridines. Doi:10.3987/com-15-13234
专利号:US-6500954-B1 优先权日:1998-06-22 标 题:Synthesis of 5- or 8-bromoisoquinoline derivatives 发明人:GOULIAEV ALEX HAAHR; HANSEN WILLIAM 权利人:NEUROSEARCH AS 摘要:The present invention is directed to a method of preparing bromoisoquinoline derivatives, in particular 5- or 8-bromoisoquinoline derivatives. Bromoisoquinoline derivatives, and in particular 5-bromoisoquinoline and 5-bromo-8-nitroisoquinoline derivatives, are key intermediates in the synthesis of pharmaceutical compounds.
专利号:DE-69911603-D1 优先权日:1998-06-22 标题:SYNTHESIS OF 5- OR 8-BROMOISOQUINOLINE DERIVATIVES
专利号:DE-69911603-T2 优先权日:1998-06-22 标题:SYNTHESIS OF 5- OR 8-BROMOISOQUINOLINE DERIVATIVES
专利号:CN-108929270-A 优先权日:2018-08-15 标 题:Synthesis of a drug intermediate disubstituted nitrogen-containing heterocyclic amine compound
专利号:US-5786482-A 优先权日:1994-07-22 标 题:Dimeric arylisoquinoline alkaloids and synthesis method thereof 发明人:BRINGMANN GERHARD; BOYD MICHAEL R; GOETZ ROLAND; KELLY T ROSS 权利人:US HEALTH; TRUSTEES BOSTON COLLEGE 摘要:The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric arylisoquinoline compounds and derivatives thereof.
专利号:AT-E250584-T1 优先权日:1998-06-22 标题:SYNTHESIS OF 5-OR 8-BROMOISOQUINOLINE DERIVATIVES
摘要:Davies, G. H. M.; Wisniewski, S. R., Science of Synthesis Knowledge Updates, (2021) 2, 130. 摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 298.