CAS: 35387-93-0; Methyl 3-Iodo-4-Methoxybenzoate

上下游产品

methanol 3-iodo-4-methoxybenzoic acid ethanol methyl 3,5-diiodo-4-methoxybenzoate6,6'-dimethoxybiphenyl-3,3'-dicarboxylic acid 4-methoxy-3-(2-methoxy-[1]naphthyl)-benzoic acid dimethyl 6,6'-dimethoxybiphenyl-3,3'-dicarboxylate methyl 4-hydroxylbenzoate

4-羟基-3,5-二碘苯甲酸甲酯置于sodium Selenide,Sodium Tetrahydroborate,Sodium Methylate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成 3-碘-4-甲氧基苯甲酸甲酯
参考文献:Iodothyronine Deiodinase Mimics. Deiodination Of O,O'-Diiodophenols By Selenium And Tellurium Reagents
标题:Iodothyronine Deiodinase Mimics. Deiodination Of O,O'-Diiodophenols By Selenium And Tellurium Reagents
摘要:To Better Understand,And In The Extension Mimic,The Action Of The Three Selenium-Containing Iodothyronine Deiodinases,O,O'-Diiodophenols Were Reacted Under Acidic Conditions With Sodium Hydrogen Telluride,Benzenetellurol,Sodium Hydrogen Selenide,Or Benzeneselenol And Under Basic Conditions With The Corresponding Deprotonated Reagents. Sodium Hydrogen Telluride Was Found To Selectively Remove One Iodine From A Variety Of 4-Substituted O,O'-Diiodophenols,Including A Protected Form Of Thyroxine (T-4) Thus,It Mimics The D1 Variety Of The Iodothyronine Deiodinases. Sodium Telluride Was A More Reactive Deiodinating Agent Toward O,O'-Diiodophenols,Often Causing Removal Of Both Halogens. Benzenetellurol And Sodium Benzenetellurolate Sometimes Showed Useful Selectivity For Monodeiodination. However,The Products Were Often Contaminated By Small Amounts Of Organotellurium Compounds. Sodium Hydrogen Selenide,Sodium Selenide,Benzeneselenol,And Sodium Benzeneselenolate Were Essentially Unreactive Toward O,O'-Diiodophenols. To Gain More Insight Into Thyroxine Inner-Ring Deiodination,Substituted 2,6-Diiodophenyl Methyl Ethers Were Treated With Some Of The Chalcogen Reagents. Reactivity And Selectivity For Monodeiodination Varied Considerably Depending On The Substituents Attached To The Aromatic Nucleus. In General,It Was Possible To Find Reagents That Could Bring About The Selective Mono-Or Dideiodination Of These Substrates.
DOI:10.1021/jo972240B

专利信息

专利号:EP-2300484-B1
优先权日:2008-05-05
标题:Novel class of spiro piperidines for the treatment of neurodegenerative diseases
发明人：BRODNEY MICHAEL AARON; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:US-2013150376-A1
优先权日:2010-04-09
标 题:Novel Sultam Compounds
发明人：BRODNEY MICHAEL AARON; EFREMOV IVAN VIKTOROVICH; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:BRODNEY MICHAEL AARON; EFREMOV IVAN VIKTOROVICH; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-106061963-B
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof