专利号:US-6217901-B1 优先权日:1999-05-25 标题:Liposome-assisted synthesis of polymeric nanoparticles 发明人:PERROTT MICHAEL G; BARRY STEPHEN E 权利人:ALNIS LLC 摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs range in size from about 20 to about 1000 nm. The SPCs have surfaces that are complementary to surface sites of target molecules, resulting in the ability of the SPCs to selectively bind to molecular targets. The molecular recognition capability of these particles enables their use in diagnostic, therapeutic, and separation applications. The SPC is formed by contacting a target template molecule with a set of building blocks solubilized in the interior of a liposome, which building blocks are then polymerized into a network to form the synthetic polymer complement in the interior of the liposome. The target templates are removed to produce complementary sites in a SPC that map the surface of the target, resulting in a water-soluble SPC nanoparticle of similar dimensions as the interior of the liposome that originally supported it and capable of molecular recognition.
专利号:US-4111933-A 优先权日:1976-04-30 标题:Protection of functional groups during reaction and their subsequent restoration 发明人:ECKERT HEINER; UGI IVAR; KABBE HANS-JOACHIM 权利人:BAYER AG 摘要:In the process for preparing an organic compound of the formula n n A' -- X n n in which n X is an amino group, a hydroxyl group or a carboxyl group, and n A' is the remainder of the molecule, from an organic compound of the formula n n A -- X n n in which n A is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formula n n A -- Z -- COOR n n in which n Z is --NH--, --O-- or a direct C--C bond, and n R is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CHâ•?CH-- group or an arylene group, n R 1 to R 4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, or n R 1 + r 2 and R 3 + R 4 each independently completes a 5- or 6-membered carbocyclic ring, or n R 1 and R 3 conjointly with the grouping --C--Y--C-- forms a carbocyclic ring with 5 or 6 carbon atoms, and Hal is halogen, n Thereby to protect X, then converting A -- Z -- COOR into a compound of the formula n n A' -- Z -- COOR n n and then treating the compound A' -- Z -- COOR to restore the group X, the improvement which comprises effecting the treatment of the compound A' -- Z -- COOR with an alkali metal compound of a complex of monovalent cobalt. The process is applicable particularly to aminocarboxylic acids including intermediates from various stages of the synthesis of penicillins and cephalosporis.
专利号:US-4466900-A 优先权日:1981-09-22 标 题:Process for the preparation of fluorescent brightener formulations which are stable on storage 发明人:HORLACHER PAUL; PFENNINGER HEINZ 权利人:CIBA GEIGY CORP 摘要:A process is described for the preparation of concentrated liquid formulations, stable on storage, of anionic fluorescent brighteners, which process consists in passing a crude (for example obtained from synthesis) aqueous solution or dispersion of a fluorescent brightener containing sulfo groups, in particular a stilbene fluorescent brightener belonging to the group comprising bistriazinylaminostilbenedisulfonic acids, bis-styrylbiphenyls, bis-styrylbenzenes and bis-triazolylstilbenedisulfonic acids, is passed through a semipermeable membrane which contains ionic groups and has a pore diameter of 1-500 ANGSTROM in order to remove salts and by-products from the synthesis having molecular weights below 500 and in order to remove part of the water. The resulting concentrated preparation can, if desired, be concentrated further and/or treated with formulation assistants and, if desired, further additives.
专利号:WO-2017064350-A1 优先权日:2015-10-15 标 题:Six-membered benzo-heterocycles having oxygen and nitrogen atoms with anti-tumour activity 发明人:CAMPOS ROSA JOAQUÃ?N MARÃ?A; GARCÃ?A RUBIÑO MARÃ?A EUGENIA; MARCHAL CORRALES JUAN ANTONIO; MORATA TARIFA CYNTHIA; RAMÃ?REZ RIVERA ALBERTO; PAZ ROJAS ALBERTO 权利人:UNIV GRANADA; CANVAX BIOTECH S L; UNIV DE JAÉN 摘要:The invention relates to a new family of six-membered benzo-heterocycles having oxygen and nitrogen atoms, joined to substituted purines, halogens and triazoles which are useful in cancer treatment, in particular in treatments whose therapeutic targets are the carcinogenic stem cells. The invention also relates to the method for the synthesis of said compounds.
专利号:US-4390342-A 优先权日:1980-04-01 标 题:Process for the preparation of solid composition of water-soluble dyes 发明人:BRUTTEL BEAT; PFENNINGER HEINZ 权利人:CIBA GEIGY CORP 摘要:A process for producing solid dye compositions, which process comprises passing an aqueous solution or suspension of at least one water-soluble crude dye, to effect separation of synthesis by-products having a molecular weight of below 500 and partial separation of water, through a semipermeable membrane, subsequently drying the resulting aqueous preparation which has become more highly concentrated, and optionally adding further additives before and/or after passage of the aqueous solution or suspension through the semipermeable membrane, these additives being added beforehand only when they do not become separated by the membrane. There are obtained by this process low-dust to dust-free compositions which are distinguished by high mechanical strength, high bulk density, free-flowing characteristics and good dissolving behavior. Employing these compositions it is possible to prepare low-foam to foam-free aqueous dye liquors having very good solution stability, even in the presence of electrolytes.
专利号:US-4500321-A 优先权日:1980-06-04 标 题:Process for the preparation of concentrated fluid dye compositions 发明人:HUGELSHOFER PAUL; BRUTTEL BEAT; PFENNINGER HEINZ; LACROIX ROGER 权利人:CIBA GEIGY CORP 摘要:A process for the preparation of storage-stable concentrated fluid dye compositions of water-soluble dyes, wherein an aqueous solution or suspension of at least one anionic crude dye is passed over a semi-permeable membrane containing ionic groups and having a pore diameter of 1 to 500 ANGSTROM , to remove salts and synthesis by-products of molecular weights less than 500 and to partially remove water, optionally dried, and mixed with a water-miscible organic solvent and, if desired, further additives, before and/or after passage over the semi-permeable membrane. The fluid dye compositions obtained are particularly suitable for use in spray solutions for dyeing leather, as well as for the dying and printing of textile materials, in particular cellulosic fibres.
[参考文献]: T Hou, Et Al. Analysis Of Multiple Samples Using Multiplex Sample Nmr: Selective Excitation And Chemical Shift Imaging Approaches. Anal Chem. 2001 Jun 1;73(11):2541-6.
合成参考文献
摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 328. 摘要:Wu, T.; Moeller, K. D., Science of Synthesis: Special Topics, (2021) 1, 487. 参考文献:10.1007/s10661-005-8042-7 摘要:Rodriguez MJ, Sérodes J. Laboratory-scale chlorination to estimate the levels of halogenated DBPs in full-scale distribution systems. Environmental Monitoring and Assessment. 2005 Nov;110(1-3):323–40. doi: 10.1007/s10661-005-8042-7.