CAS: 6305-95-9; 1-(2-Chlorophenyl)Propan-2-One

该化合物是一种有机化合物,其特点是芳香结构,和氯酮功能组,其特点是一种附于丙酮混合物的氯化苯环,有助于其反应和有机合成的潜在应用;该化合物一般是无色的,可粉黄,具有独特的气味;在乙醇和乙醚等有机溶剂中具有中度溶解性,但由于其疏水性,溶解性有限;氯原子的存在增强了其电子药理特性,使其在各种化学反应中有用,包括核乐类替代剂和作为合成药物和农用化学品的中间体;在处理2-氯苯丙酮时,安全考虑十分重要,因为若吸入或摄入,可能会对健康造成危害;应当采取适当的保护措施;

结构式图片

欧盟法规

C&L通报

上下游产品

pyridine 2'-chloro-benzeneacetic acid acetic anhydride 1ξ-(2-chloro-phenyl)-2-nitro-propene 2-methyl-1H-indole o-chlorophenylacetone oxime 3-(2-chloro-phenyl)-4-phenyl-butan-2-one 3,4-bis-(2-chloro-phenyl)-butan-2-one

合成工艺路线路线简述

    邻氯苯乙酸置于n,N-二异丙基乙胺,Methanaminium,N-[(Dimethylamino)(3H-1,2,3-Triazolo[4,5-B]Pyridin-3-Yloxy)Methylene]-N-Methyl-,Hexafluorophosphate(1-)体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成 2-氯苯基乙酮
    参考文献: Inhibiting Cyclic Amp-Responsive Element-Binding Protein (Creb)[fr] Inhibition De La Protéine De Liaison à Un élément Sensible à L'Amp Cyclique (Creb)
    标题: Inhibiting Cyclic Amp-Responsive Element-Binding Protein (Creb)[fr] Inhibition De La Protéine De Liaison à Un élément Sensible à L'Amp Cyclique (Creb)
    摘要:本公开涉及抑制cbp/p300家族溴结构域的抑制剂.这些化合物可用于治疗与抑制cbp/p300家族溴结构域相关的疾病或疾病.例如,该公开涉及用于抑制cbp/p300家族溴结构域的化合物和组合物,治疗与抑制cbp/p300家族溴结构域相关的疾病或疾病的方法(例如,某些形式的癌症),以及这些化合物的合成方法.

    海关参考信息

    专利信息


    专利号:US-12351577-B2
    优先权日:2019-03-15
    标题 :Inhibiting cyclic AMP-responsive element-binding protein (CREB)
    发明人:SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; ERICSSON ANNA; DOWNING JENNIFER R
    权利人:FORMA THERAPEUTICS INC
    摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.

    专利号:CN-115433958-B
    优先权日:2021-06-03
    标 题 :Electrochemical synthesis of 2-aminothiazole compounds

    专利号:US-8178559-B2
    优先权日:2004-12-30
    标 题:Organic compounds
    发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
    权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
    摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

    专利号:CN-107118103-A
    优先权日:2017-06-29
    标 题:A kind of insecticide indoxacarb intermediate and its synthesis technique

    专利号:CN-108383703-A
    优先权日:2018-03-30
    标 题:A kind of 3 '-chlorophenylpropanol synthesis technique

    专利号:CN-117126044-A
    优先权日:2023-04-12
    标 题 :A microwave-assisted synthesis method of methyl ketone compounds
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Development Of General Methods For The Synthesis Of New Substituted Allyl Bromides As Promising Alkenylating Agents
    作者:A. I. Moskalenko,V. I. Boev |发布日期:2014.7
    摘要:A General Procedure Has Been Developed For The Synthesis Of Hitherto Unknown Substituted Allyl Bromides. The Procedure Includes Preparation Of The Corresponding α,β-Unsaturated Carboxylic Acid Esters From Accessible Ketones According To The Horner-Emmons Reaction, Reduction Of These Esters With Diisobutylaluminum Hydride To Allylic Alcohols, And Substitution Of The Hydroxy Group By Bromine By The Action

    合成参考文献


    参考文献:10.1055/s-0040-1707887
    摘要:Richardson J, Mutton SP, Martin FM, Walton L, Ledgard AJ. An Efficient Palladium-Catalyzed α-Arylation of Acetone Below its Boiling Point. Synlett. 2020 Jul 09;31(15):1532–6. doi: 10.1055/s-0040-1707887.
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