CAS: 7463-51-6; 4-Bromo-3,5-Dimethylphenol

上下游产品

CAS号108-68-9 3,5-二甲基苯酚 | CAS号7726-95-6 溴素 | CAS号64-19-7 冰醋酸 | CAS号361543-99-9 2.6-二甲基-4-甲氧基苯硼酸 | CAS号58537-99-8 4-羟基-2,6-二甲基苯甲腈 | CAS号1943-54-0 2,6-Dichloro-3,... | CAS号301537-10-0 2-(BROMOMETHYL)... | CAS号28924-92-7 4-苄氧基-2,6-二甲基苯甲醛 | CAS号70547-87-4 2,6-二甲基-4-羟基苯甲醛 | CAS号6267-34-1 2-溴-5-甲氧基-1,3-二甲苯 | CAS号77665-04-4 1-bromo-2-metho... | CAS号68293-32-3 7-羟基-5-甲基-1-茚酮 | CAS号805250-50-4 3-[4-(2-ethoxye...

3,5-二甲基苯酚置于1,2-Ethanediylbis(Triphenylphosphonium) Ditribromide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 0.08H,以90%的收率获得产物4-溴-3,5-二甲酚
参考文献:在溶剂存在下和无溶剂条件下合成1,2-乙二基双(三苯基phosph)二溴化新溴化剂
标题:在溶剂存在下和无溶剂条件下合成1,2-乙二基双(三苯基phosph)二溴化新溴化剂
摘要:摘要定量制备了1,2-乙二烷基双(三苯基))二三溴化物,并在混合溶剂系统(dcm / Meoh 2:1)的存在下以及在无溶剂条件下用于苯胺和苯酚的溴化.这种新型离子液体在反应时间短,后处理简单,区域选择性高和产率方面均优于同类溴化剂.标题盐的单晶x射线分析表明,双三苯基phosph阳离子围绕位于-ch 2-ch 2-桥中心的反型中心周围组织,并且两个三苯基膦链段彼此相对.所有三溴化物阴离子均采用线性几何结构,每个阴离子具有不同的br-br-br键角. 图形概要
DOI:10.1007/s13738-016-0919-6

专利信息

专利号:US-2004014168-A1
优先权日:1998-06-11
标题:Reagents and methods for library synthesis and screening
发明人：SCHREIBER STUART L; BLACKWELL HELEN E; PEREZ FERNANDEZ LUCY; TALLARICO JOHN A
权利人:HUGHES HOWARD MED INST
摘要:The invention provides novel solid supports for the synthesis of compound libraries. The solid supports have the physical capacity to deliver at least 50 nmol of compound and are functionalized with a silicon-containing linker. In one embodiment of the invention the solid support comprises a bead having a diameter of between approximately 400 and 600 μm functionalized with a silicon-containing linker. According to certain embodiments of the invention the bead is a polystyrene bead. According to certain embodiments of the invention the linker is a diisopropylalkyl-substituted silyl ether. The invention further provides grafted polymeric supports such as lanterns functionalized with a silicon-containing linker. n The invention provides methods for screening in which compounds are synthesized on solid supports in a quantity so that a single solid support such as a bead provides a stock solution sufficient to perform hundreds or thousands of biological or chemical assays. The methods include decoding the sequence of chemical reactions used to synthesize the compound by identifying tags incorporated into the compound during synthesis.

专利号:US-2025026871-A1
优先权日:2021-04-06
标 题:Cyclic ruthenium benzylidene initiators for enhanced ring expansion metathesis polymerization
发明人：GOLDER MATTHEW; WANG TENG-WEI; JOHNSON JEREMIAH A
权利人:UNIV WASHINGTON; MASSACHUSETTS INSTITUTE OF TECH M I T; MASSACHUSETTS INST TECHNOLOGY
摘要:Cyclic ruthenium benzylidene initiators useful for the controlled synthesis of functionalized cyclic macromolecules via ring-expansion metathesis polymerization.

专利号:US-6162932-A
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
发明人：MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JENG; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP
摘要:The present invention is directed to chiral intermediates in a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A). ##STR1##

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-9717071-A1
优先权日:1995-11-08
标 题 :Stereoselective synthesis of endothelin receptor antagonists
发明人：MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI-JEN; GOMBATZ KERRY JOSEPH
权利人:SMITHKLINE BEECHAM CORP; MILLS ROBERT JOHN; KOWALSKI CONRAD JOHN; PING LI JEN; GOMBATZ KERRY JOSEPH
摘要:The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.