CAS: 87392-05-0; (R)-2-Tetrahydrofuroic Acid

• 英文名称(R)-2-Tetrahydrofuroic Acid
• 中文名称(R)-四氢呋喃甲酸
• IUPAC名称(R)-tetrahydrofuran-2-carboxylic acid
• 其它别名(R)-(+)-2-Tetrahydrofuroicacid; (R)-2-Tetrahydrofuroic Acid; (R)-(+)-Tetrahydro-2-Furoic Acid, ; (R)-Tetrahydrofuran- 2-Carboxylic Acid; Tetrahydro-Furan-2-Carboxylic Acid; (R)-(+)-2-Tetrahydrofuroic Acid; (R)-(+)-Tetrahydrofuran-2-Car
• CAS编号87392-05-0
• MFCD编号:MFCD00211271
• EINECS号:627-523-2
• FDA UNII编号:7396HFQ44J
• 分子式:C5H8O3
• 分子量:116.12
• 产品CID: 1880420
• 产品分类医药中间体 → 原料药中间体

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: UJJLJRQIPMGXEZ-SCSAIBSYSA-N
• InChI=1S/C5H8O3/c6-5(7)4-2-1-3-8-4/h4H,1-3H2,(H,6,7)/t4-/m1/s1…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

物理性质

• 熔点128-129 °C 13 mm Hg(文献)
• 沸点243.2±0.0 °C at 760 mmHg
• 闪点113.2±18.9 °C
• 密度1.3±0.1 g/cm3
• PH:+19.6±0.2°(neat) (D/20°C)
• pKa:3.60±0.20(预测)
• PSA:46.53
• LogP:-0.61
• 折射率1.480
• 蒸汽压0.0±1.0 mmHg at 25°C
• 敏感性按规定使用和贮存的不会分解，避氧化物
• 外观形态无色至淡黄色透明液体
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用于中间药剂.
• 性质描述密度1.209,沸点244°C,折射率1.459-1.461

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经口)
  皮肤腐蚀 类别1B
  皮肤腐蚀 类别1C
  严重眼损伤 类别1
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
• 防范说明P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
• 危险等级8
• UN编号UN 3265 8/PG 3
• 危险品标志C,Xi
• 包装等级III
• 安全声明26-36/37/39-45-36
• 危险类别码22-34-36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 (R)-(+)-Tetrahydro-2-Furoic Acid 主要起始原料 2-Tetrahydrofuroic Acid
• 375825-12-0 = 87392-05-0
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 0 °C -> 25 °C; 30 Min,25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Chiral Ammonium Hypoiodite Salt-Catalyzed Enantioselective Oxidative Cycloetherification To 2-Acyl Tetrahydrofurans
  作者:Uyanik,Muhammet; Et Al
  参考文献:Chemistry Letters 日期:2016 卷标:45(3) 页码:353-355]
  
  16874-34-3 = 87392-05-0
  反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Proteinase Solvents: Water; 20 H,Ph 10,10 °C1.2 Reagents: Hydrochloric Acid,Ammonium Sulfate Solvents: Water; Ph 21.3 Solvents: Tert-Butyl Methyl Ether
  标题:A Scalable Chemoenzymic Preparation Of (R)-Tetrahydrofuran-2-Carboxylic Acid
  作者:Fujima,Yoshito; Et Al
  参考文献:Tetrahedron: Asymmetry 日期:2003 卷标:14(10) 页码:1385-1391]
  
  = 87392-05-0
  反应条件:1.1 Reagents: Titanium Ethoxide Catalysts: Palladium Dihydroxide Solvents: N-Methyl-2-Pyrrolidone; 22 H,30 Bar,Rt2.1 Reagents: Hydrochloric Acid Solvents: Water; 20 H,90 °C; Cooled2.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 5
  标题:Highly Diastereoselective Hydrogenation Of Furan-2-Carboxylic Acid Derivatives On Heterogeneous Catalysts
  作者:Sebek,Michael; Et Al
  参考文献:Synlett 日期:2009 卷标:(3) 页码:461-465]
  
  16874-33-2 = 87392-05-0
  反应条件:1.1 Reagents: Sulfuric Acid Solvents: Toluene,Water; Rt; 6 H,75 - 77 °C; 77 °C -> Rt1.2 Reagents: Ammonium Sulfate Solvents: Water2.1 Reagents: Sulfuric Acid,Ammonium Sulfate Catalysts: Triacylglycerol Lipase Solvents: Isopropanol,Water
  标题:A Scalable Chemoenzymic Preparation Of (R)-Tetrahydrofuran-2-Carboxylic Acid
  作者:Fujima,Yoshito; Et Al
  参考文献:Tetrahedron: Asymmetry 日期:2003 卷标:14(10) 页码:1385-1391]
  
  112068-01-6 = 87392-05-0
  反应条件:1.1 Reagents: Cesium Carbonate Solvents: Acetonitrile; 30 Min,Rt1.2 4 H,Rt2.1 Reagents: Titanium Ethoxide Catalysts: Palladium Dihydroxide Solvents: N-Methyl-2-Pyrrolidone; 22 H,30 Bar,Rt3.1 Reagents: Hydrochloric Acid Solvents: Water; 20 H,90 °C; Cooled3.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 5
  标题:Highly Diastereoselective Hydrogenation Of Furan-2-Carboxylic Acid Derivatives On Heterogeneous Catalysts
  作者:Sebek,Michael; Et Al
  参考文献:Synlett 日期:2009 卷标:(3) 页码:461-465]
  
  1152061-22-7 = 87392-05-0
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 20 H,90 °C; Cooled1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 5
  标题:Highly Diastereoselective Hydrogenation Of Furan-2-Carboxylic Acid Derivatives On Heterogeneous Catalysts
  作者:Sebek,Michael; Et Al
  参考文献:Synlett 日期:2009 卷标:(3) 页码:461-465]
  
  16874-33-2 = 87392-05-0
  反应条件:1.1 Reagents: (S)-1-Phenylethylamine Solvents: Dichloromethane,Ethyl Acetate; Rt; Rt -> Reflux; 15 Min,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Dichloromethane,Water; 30 Min,Ph 13,Reflux
  标题:Synthesis Of (2R)-Tetrahydro-2-Furancarbothioic Acid [r-(+)-Thiotetrahydrofuran-2-Carboxylic Acid]
  作者:Li,Juan; Et Al
  参考文献:Shenyang Yaoke Daxue Xuebao 日期:2008 卷标:25(9) 页码:714-715]
  
  37443-42-8 = 87392-05-0
  反应条件:1.1 Reagents: Sulfuric Acid,Ammonium Sulfate Catalysts: Triacylglycerol Lipase Solvents: Isopropanol,Water
  标题:A Scalable Chemoenzymic Preparation Of (R)-Tetrahydrofuran-2-Carboxylic Acid
  作者:Fujima,Yoshito; Et Al
  参考文献:Tetrahedron: Asymmetry 日期:2003 卷标:14(10) 页码:1385-1391]
  
  112068-01-6 + 16874-33-2 = 87392-05-0
  反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran; 45 Min,Rt1.2 24 H,Rt2.1 Reagents: Hydrochloric Acid Solvents: Water; 20 H,90 °C; Cooled2.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 5
  标题:Highly Diastereoselective Hydrogenation Of Furan-2-Carboxylic Acid Derivatives On Heterogeneous Catalysts
  作者:Sebek,Michael; Et Al
  参考文献:Synlett 日期:2009 卷标:(3) 页码:461-465]
  
  16874-33-2 = 87392-05-0
  反应条件:1.1 Reagents: Sulfuric Acid Solvents: Toluene,Water; Rt; 4.5 H,Reflux; Reflux -> Rt1.2 Reagents: Sulfuric Acid Solvents: Water; Reflux; Reflux -> Rt1.3 Solvents: Toluene2.1 Reagents: Potassium Hydroxide Catalysts: Proteinase Solvents: Water; 20 H,Ph 10,10 °C2.2 Reagents: Hydrochloric Acid,Ammonium Sulfate Solvents: Water; Ph 22.3 Solvents: Tert-Butyl Methyl Ether
  标题:A Scalable Chemoenzymic Preparation Of (R)-Tetrahydrofuran-2-Carboxylic Acid
  作者:Fujima,Yoshito; Et Al
  参考文献:Tetrahedron: Asymmetry 日期:2003 卷标:14(10) 页码:1385-1391]
  
  1980876-53-6 + 71-36-3 = 87392-05-0
  反应条件:1.1 Reagents: Methyl Triflate Solvents: Dichloromethane; 25 °C; 1 H,Rt1.2 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene; 30 Min,Rt2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 0 °C -> 25 °C; 30 Min,25 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Chiral Ammonium Hypoiodite Salt-Catalyzed Enantioselective Oxidative Cycloetherification To 2-Acyl Tetrahydrofurans
  作者:Uyanik,Muhammet; Et Al
  参考文献:Chemistry Letters 日期:2016 卷标:45(3) 页码:353-355]
  
  = 87392-05-0
  反应条件:1.1 Reagents: Cumene Hydroperoxide Catalysts: 4,4′-Spirobi[4H-Dinaphth[2,1-C:1′,2′-E]Azepinium],3,3′,5,5′-Tetrahydro-2,6-Bis[... Solvents: Tert-Butyl Methyl Ether; 2 H,25 °C2.1 Reagents: Methyl Triflate Solvents: Dichloromethane; 25 °C; 1 H,Rt2.2 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene; 30 Min,Rt3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 0 °C -> 25 °C; 30 Min,25 °C3.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Chiral Ammonium Hypoiodite Salt-Catalyzed Enantioselective Oxidative Cycloetherification To 2-Acyl Tetrahydrofurans
  作者:Uyanik,Muhammet; Et Al
  参考文献:Chemistry Letters 日期:2016 卷标:45(3) 页码:353-355

海关参考信息

• 2905122000-异丙醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
  2909110000-乙醚
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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• ➥ 防范代码详解
• ➥ 危险代码说明
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