2-甲基-4-甲氧基苯胺置于盐酸,N-溴代丁二酰亚胺(Nbs),Ammonium Hexafluorophosphate,Sodium Carbonate,二甲基亚砜,Sodium Nitrite体系中,用 四氯化碳 用作溶剂,化学反应 25.0H,反应生成2-氟-5-甲氧基苯甲醛 参考文献:Steric Effects On Atropisomerism In Tetraarylporphyrins 标题:Steric Effects On Atropisomerism In Tetraarylporphyrins 摘要: Doi:10.1021/ja00236A008
专利信息
专利号:WO-2021038581-A1 优先权日:2019-08-30 标题 :A one step synthesis of 2-substituted benzo[b]thiophenes 发明人:SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI 权利人:INDIAN INST TECH MADRAS 摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.
专利号:US-9067934-B2 优先权日:2011-03-31 标题 :Bicyclic pyridinones 发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:RU-2162076-C2 优先权日:1995-06-07 标 题 :Derivatives of n-acyl-2-arylcycloalkylamine stimulating melatonin synthesis, pharmaceutical composition, method of melatonin-stimulating binding
专利号:WO-2010039911-A1 优先权日:2008-10-01 标题 :Calcilytic compounds 发明人:JEONG JAE U; MARQUIS ROBERT W JR 权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
专利号:CN-104098577-B 优先权日:2014-07-12 标 题:A kind of high-efficiency synthesis method of azoloindolone condensed heterocyclic ring
[参考文献]: Yumiko Suzuki, Et Al. Xanthone Natural Products Via N-Heterocyclic Carbene Catalysis: Total Synthesis Of Atroviridin. J Org Chem. 2011 May 20;76(10):3960-7.
合成参考文献
摘要:Scholz, U.; Schlummer, B., Science of Synthesis, (2007) 31, 1579.