CAS: 2971-79-1; Methyl Piperidine-4-Carboxylate

上下游产品

CAS号2459-09-8 异烟酸甲酯 | CAS号67-56-1 甲醇 | CAS号498-94-2 4-哌啶甲酸 | CAS号1083159-12-9 O2-(2,4-dinitro... | CAS号84358-13-4 1-B°C-4-哌啶甲酸 | CAS号55-22-1 异烟酸 | CAS号857778-39-3 4-bromo-2-(2-br... | CAS号889126-33-4 1-(2-氯嘧啶-4-基)哌啶... | CAS号1085755-63-0 methyl 1-(2-chl... | CAS号1085755-96-9 methyl 1-(2-met... | CAS号99455-05-7 6-溴-2-甲氧基喹啉 | CAS号187834-88-4 1-B°C-4-哌啶甲酰肼 | CAS号6457-49-4 4-哌啶甲醇 | CAS号67686-01-5 1-苄基-4-哌啶甲醇 | CAS号138163-07-2 1-Cbz-哌啶-4-甲酸甲酯 | CAS号331828-49-0 1-(4-NITRO-BENZ... | CAS号124443-68-1 N-B°C-4-哌啶甲酸甲酯

异烟酸甲酯置于platinum On Carbon,氢气体系中,用 溶剂黄146 用作溶剂,80.0 °C,3.0 Mpa 条件下,以93%的收率获得4-哌啶甲酸甲酯
参考文献:功能化吡啶的连续流动氢化
标题:功能化吡啶的连续流动氢化
摘要:取代吡啶的多相加氢是通过采用连续流动加氢装置完成的,该装置结合了通过电解水和预装催化剂盒原位产生氢气.总的来说,无论负载的贵金属催化剂(pd/c,Pt/c或rh/c)如何,加氢反应都能顺利进行.通过在 60-80 oc 下使用 30-80 Bar 的氢气压力,通常可以在所有情况下以 0.5 Ml Min-1 的流速实现完全转化,从而以高收率提供相应的哌啶.对于二取代吡啶,观测到立体选择性的变化取决于金属催化剂和氢化反应的温度/压力.对于烟酸乙酯,部分氢化和完全氢化之间的选择性可以根据氢气压力进行调整,溶剂,以及负载型金属催化剂的选择.将氢源从 H2O 更改为 D2O 可以制备氘代衍生物.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2009)
Doi:10.1002/ejoc.200801131

专利信息

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:US-12180182-B2
优先权日:2021-12-01
标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
发明人：DAI MINGJI
权利人:PURDUE RESEARCH FOUNDATION
摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-9815816-B2
优先权日:2005-09-30
标 题 :Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
发明人：BLIXT JORGEN; GOLDEN MICHAEL DAVID; HOGAN PHILIP JOHN; MARTIN DAVID MICHAEL GLANVILLE; MONTGOMERY FRANCIS JOSEPH; PATEL ZAKARIYA; PITTAM JOHN DAVID; SEPENDA GEORGE JOSEPH; SQUIRE CHRISTOPHER JOHN; WRIGHT NICHOLAS CARTWRIGHT ALEXANDER
权利人:ASTRAZENECA AB; GENZYME CORP
摘要:The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

专利号:US-2019263782-A1
优先权日:2005-09-30
标 题 :Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline

专利号:US-12351577-B2
优先权日:2019-03-15
标题 :Inhibiting cyclic AMP-responsive element-binding protein (CREB)
发明人：SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; ERICSSON ANNA; DOWNING JENNIFER R
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.