CAS: 31949-21-0; 2-Bromo-1-(2-Methoxyphenyl)Ethanone

上下游产品

α,α-Dibromo-2'-Methoxyacetophenone 1121543-12-1
2'-甲氧基苯乙酮 2-Methoxyacetophenone 579-74-8
2'-羟基苯乙酮 O-Hydroxyacetophenone 118-93-4

2'-羟基苯乙酮置于potassium Hydroxide,Copper(Ll) Bromide体系中,用 氯仿,二甲基亚砜,乙酸乙酯 作为反应溶剂,化学反应 0.33H,反应生成 邻甲氧基-2-溴苯乙酮
参考文献:使用串联交叉复分解/分子内氢化芳基化序列的功能化四氢咔唑的高效途径
标题:使用串联交叉复分解/分子内氢化芳基化序列的功能化四氢咔唑的高效途径
摘要:描述了新型钌催化的串联交叉复分解/分子内氢芳基化序列的范围.这种方法可以有效,高效地合成结构多样且复杂的四氢咔唑(高达98%).而且,提出了通过用钌配合物和手性胺的顺序催化来开发当前方法的对映选择性形式的初步努力,其具有高收率和对映选择性(高达88%的收率和91%的ee).
DOI:10.1002/asia.201000315

专利信息

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-4997945-A
优先权日:1990-01-25
标 题:Carbamate salts of 2-(2'-thienyl)alkylamines
发明人：KHATRI HIRALAL N
权利人:SYNTEX INC
摘要:The carbamate salt of 2-(2'-thienyl)-alkylamines and particularly the ethylamine and its method of synthesis are disclosed. The carbamate salt of 2-(2'-thienyl)ethylamine is a stable, easily transportable crystalline material that can be converted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of 5[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine hydrochloride, also known as ticlopidine hydrochloride. The synthesis is carried out by reacting an amine of formula (I): (I) with CO2 in a hydrocarbon solvent to obtain the carbamate salt of formula II: II

专利号:US-4906756-A
优先权日:1988-05-10
标 题 :2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
发明人：LODEWIJK ERIC; KHATRI HIRALAL N
权利人:SYNTEX INC
摘要:An improved process for the reduction of 2-(2-nitrovinyl)thiophene to form 2-(2-thienyl)ethylamine employs a boron-containing reducing agent, preferably diborane. The 2-(2-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:EP-0522956-B1
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
发明人：HARRINGTON PETER J; SANCHEZ IGNACIO H
权利人:SANOFI SA
摘要:Compounds of the formulae: and wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

专利号:US-8906915-B2
优先权日:2009-12-17
标 题:Compounds, compositions, and methods for controlling biofilms
发明人：DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S
权利人:DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S; UNIV LEUVEN KATH
摘要:The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.