2-Hydroxyl-5-Carboxylbenzenesulfonic Acid置于水,氯体系中,化学反应生成3,5-二氯-4-羟基苯甲酸 参考文献:Datta; Mitter,Journal Of The American Chemical Society,1919,Vol. 41,P. 2038 标题:Datta; Mitter,Journal Of The American Chemical Society,1919,Vol. 41,P. 2038
专利号:WO-2025103334-A1 优先权日:2023-11-16 标 题 :Preparation method and use of dotinurad 发明人:CHEN HONGJUN; WANG ZHONGQING; LIAO SHOUZHU; PING YULEI; Wu Binpeng 权利人:SUNSHINE LAKE PHARMA CO LTD 摘要:The present invention provides a preparation method and use of Dotinurad. Specifically, a synthesis method for Dotinurad provided by the present invention is mainly characterized in that an ester group is introduced into a route, avoiding a high temperature reaction in a methoxyl compound demethylation step in the prior art. Additionally, the preparation method of the present invention involves cheap raw materials, simple operation, mild conditions and short steps, and the prepared Dotinurad involves simple post-treatment and has high purity.
专利号:US-2014378541-A1 优先权日:2011-06-16 标题 :Synthetic Epigallocatechin Gallate (EGCG) Analogs 发明人:CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI 权利人:CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI; UNIV WAYNE STATE; UNIV MCGILL; UNIV HONG KONG POLYTECHNIC 摘要:Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.
专利号:EP-2968667-A1 优先权日:2013-03-14 标题:Peg-based adhesive phenylic derivatives and methods of synthesis and use
专利号:US-2016032047-A1 优先权日:2013-03-14 标题 :Peg-based adhesive phenylic derivatives and methods of synthesis and use
专利号:CA-2905840-A1 优先权日:2013-03-14 标题 :Peg-based adhesive phenylic derivatives and methods of synthesis and use
专利号:CN-113429308-A 优先权日:2021-06-16 标题 :The synthesis process of diclofenac sodium
[参考文献]: Michael F Wempe, Et Al. Potent Human Uric Acid Transporter 1 Inhibitors: In Vitro And In Vivo Metabolism And Pharmacokinetic Studies. Drug Des Devel Ther. 2012:6:323-39. [参考文献]: Petra Lovecka, Et Al. Study Of Cytotoxic Effects Of Benzonitrile Pesticides. Biomed Res Int. 2015:2015:381264.
合成参考文献
摘要:Journal of Medicinal and Pharmaceutical Chemistry., 2(213), 1960 [] 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 摘要:A. Fischer, G. J. Leary, R. D. Topsom and J. Vaughan, J. Chem. Soc. (B) 1967, 686.