CAS: 40155-42-8; 5-Methoxypyrazine-2-Carboxylic Acid

相似化合物

38789-75-2 54013-05-7 72788-88-6

上下游产品

CAS号36070-80-1 5-氯吡嗪-2-羧酸 | CAS号67-56-1 甲醇

5-羟基吡嗪-2-羧酸置于氯化亚砜,硫酸体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 21.5H,反应生成 5-甲氧基吡嗪-2-甲酸
参考文献: Selective octahydro-Cyclopenta[c] Pyrrole Negative Modulators Of Nr2B[fr] Modulateurs De Nrb2,à Base D'octahydro-Cyclopenta[c] Pyrrole,à Modulation Négative Sélective
标题: Selective octahydro-Cyclopenta[c] Pyrrole Negative Modulators Of Nr2B[fr] Modulateurs De Nrb2,à Base D'octahydro-Cyclopenta[c] Pyrrole,à Modulation Négative Sélective
摘要:揭示了选择性负性调节含有nr1/nr2B亚基的nmda受体的化合物,包括该化合物的药物组合物,以及使用该化合物治疗疾病的方法.这些疾病包括但不限于神经功能障碍,如帕金森病,亨廷顿病,肌萎缩侧索硬化,多发性硬化和癫痫症;情绪障碍;抑郁症;躁郁症;强迫症;以及其他焦虑障碍.

专利信息

专利号:US-2016090360-A1
优先权日:2013-04-26
标题:Synthesis of bace inhibitors
发明人：FETTES ALEC; MARTY HANS-PETER; SCALONE MICHELANGELO
权利人:HOFFMANN LA ROCHE
摘要:The present invention provides a one step carbonylation of a compound of formula II in the presence of water to afford a compound of formula (I), useful in processes to manufacture BACE inhibitors.

专利号:US-8962858-B2
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
发明人：MITASEV BRANKO; KIM DAE-SHIK; ZHANG HUIMING; FARTHING CHRISTOPHER N
权利人:EISAI R&D MAN CO LTD
摘要:Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

专利号:US-8802871-B2
优先权日:2011-01-21
标 题:Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:US-2013197244-A1
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:CA-2814014-A1
优先权日:2011-01-21
标 题:Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:CA-2909136-A1
优先权日:2013-04-26
标题 :Synthesis of bace inhibitors