专利号:WO-2021038419-A1 优先权日:2019-08-23 标题 :Kinase inhibitors and methods of synthesis and treatment 发明人:ZAVORONKOVS ALEKSANDRS; IVANENKOV YAN; POLYKOVSKIY DANIIL; ALIPER ALEKSANDR 权利人:INSILICO MEDICINE IP LTD 摘要:Compounds that function as kinase inhibitors are provided. The kinase inhibitors can have any structure of the formulae provided herein, such as shown for Compounds 1-4. A pharmaceutical composition can include: the compound of one of the embodiments; and a pharmaceutically acceptable carrier having the compound. A method of inhibiting a kinase can include: providing the compound of one of the embodiments described herein to the kinase such that the kinase is inhibited. The methods can include inhibiting DDR1 and/or DDR2, and thereby providing a modulation or decrease in the activity of DDR1 and/or DDR2. This decrease in DDR1 and/or DDR2 activity can be used as therapy to treat conditions related to DDR1 and/or DDR2 activity, such as fibrosis, cancer, and others.
专利号:WO-2016187028-A1 优先权日:2015-05-15 标 题 :Heteroaryl compounds, synthesis thereof, and intermediates thereto 发明人:FERNANDEZ PAUL FRANK; FERRETTI ANTONIO CHRISTIAN; HAN JIANXIN; TRAVERSE JOHN; TUNG HSIEN-HSIN; YONG KELVIN HIN-YEONG; ZOU NANFEI 权利人:CELGENE AVILOMICS RES INC 摘要:The present invention relates to methods for synthesizing compounds useful as inhibitors or both of ERK1 and ERK2 kinase, derivatives thereof, and intermediates thereto.
专利号:US-4338318-A 优先权日:1979-03-23 标 题 :Novel compositions and methods 发明人:HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C 权利人:ZOECON CORP 摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.
专利号:US-4297297-A 优先权日:1979-03-23 标题 :α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates 发明人:HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C 权利人:ZOECON CORP 摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.
专利号:US-4266056-A 优先权日:1978-04-07 标 题 :Phenyl uracils 发明人:HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C 权利人:ZOECON CORP 摘要:Phenyl uracils, synthesis and intermediates therefor, and compositions for the control of pests, especially fungi and bacteria.
[参考文献]: T Suzuki, Et Al. Synthesis And Histone Deacetylase Inhibitory Activity Of New Benzamide Derivatives. J Med Chem. 1999 Jul 29;42(15):3001-3.
合成参考文献
摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 428. 摘要:C.K. Hancock, R.A. Brown and J.P. Idoux. J. Org. Chem. 33, 1947 (1968).