CAS: 61832-41-5; N-Methyl-1-(Methylthio)-2-Nitroethenamine

上下游产品

nitromethane methyl carbonimidodithioic acid dimethyl ester methylamine 1,1-di(methylsulfanyl)-2-nitroethyleneN,N'-dimethyl-2-nitro-1,1-ethenediamine methylthiol ranitidine nizatidine

甲胺,1,1-双(甲硫基)-2-亚硝基乙烯 以 水 作为反应溶剂,化学反应 6.0H,反应生成 N-甲基-1-甲硫基-2-硝基乙烯胺
参考文献:水中新型螺[吲哚啉-3,5'-吡喃并[2,3-D]嘧啶]衍生物的简单环保合成
标题:水中新型螺[吲哚啉-3,5'-吡喃并[2,3-D]嘧啶]衍生物的简单环保合成
摘要:摘要通过添加反应生成的n-烷基-1-(甲硫基)-2-硝基乙胺的多组分反应,可以高收率实现绿色,便捷,高效的一锅合成新型螺[吲哚啉吡喃并嘧啶]衍生物.回流条件下,在水中将各种胺与硝基和巴比妥酸衍生物合成为硝基烯酮二硫缩醛.值得注意的是,本方法提供了期望的优点,包括非常好的收率,使用水作为绿色溶剂,不存在催化剂,简单的后处理程序以及不使用色谱技术的容易的纯化方法. 图形概要
DOI:10.1007/s00706-019-2356-6

专利信息

专利号:WO-0029400-A3
优先权日:1998-11-19
标题 :Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides
发明人：STANKOVI SLOBODAN; STOJANOVIC NEBOJSA; STOJICIC STANISLAVA; MILENOVIC DRAGAN
权利人:DD ZDRAVLJE FARMACEUTSKO HEMIJ; STANKOVI SLOBODAN; STOJANOVIC NEBOJSA; STOJICIC STANISLAVA; MILENOVIC DRAGANE
摘要:This invention is related to the procedure for obtaining of the therapeutically active N-[2[[[5-[(dialkylamino methyl]-2-furanyl] methyl] thio] ethyl]-N'-alky-2-nitro1,1 alkenediamines) of formula (I) and their hydrochlorides of formula (II), where R1, R2 and R3 are alkyl groups (C1-C4), and X is nitro-alkenic group by reaction of 2[[[5-[(dimethylamino-methyl-2-furanyl]methyl]thio]-ethanamine-hydrochloride) and N-methyl-1(methylthio-2-nitroethenamine) in the aqueous environment at the mild temperature.

专利号:US-4967007-A
优先权日:1989-05-10
标 题 :Improved process for the preparation of 1-substituted amino-1-substituted thio-2-nitro alkenes
发明人：DESHMUKH ABDUL R A S; BHAWAL BABURAO M; SHIRALKAR VASUDEO P; RAJAPPA SRINIVASACHARI
权利人:COUNCIL SCIENT IND RES
摘要:A process is disclosed for the manufacture of 1-substituted amino-1-substituted thio-2 nitro alkenes of the general formula: (R1NH) (R2S) Câ•?CR3 (NO2) wherein R1, R2, R3, may be same or different and may consist of hydrogen, alkyl, aryl or arylalkyl groups or combinations thereof. These alkenes are prepared by reacting a primary amine with a compound of sulfur in the presence of a primary catalyst to obtain a carbonimidodithioic acid salt which is converted to a corresponding ester which is thereafter reacted with a nitro compound in the presence of a secondary catalyst. 1-methylamino-1-methylthio-2-nitroethene is an important intermediate in the synthesis of Rantitidine and Nizatidine which are used as effective drugs in the treatment of peptic ulcers and associated gastrointestinal disorders.

专利号:WO-0029400-A2
优先权日:1998-11-19
标 题 :Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

专利号:CN-107501216-B
优先权日:2017-08-03
标 题:Novel synthesis method of high-stability bismuth citrate ranitidine

专利号:CN-1724526-A
优先权日:2005-07-11
标 题:Synthesis method of ranitidine alkali and its hydrochloride