CAS: 62147-27-7; Benzyl (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylate Hydrochloride

上下游产品

N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester(2S,4R)-benzyl 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxylate (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid

N-(叔丁氧羰基)-4-羟基脯氨酸苄酯置于盐酸体系中,用 乙酸乙酯 作为反应溶剂,化学反应 3.0H,反应生成 L-4-羟基脯氨酸苄酯 盐酸盐
参考文献: (4-Hydroxypyrrolidin-2-yl)-Hydroxamate Compounds And Methods Of Use Thereof[fr] Composés De (4-Hydroxypyrrolidin-2-yl)-Hydroxamate Et Leurs Procédés D'Utilisation
标题: (4-Hydroxypyrrolidin-2-yl)-Hydroxamate Compounds And Methods Of Use Thereof[fr] Composés De (4-Hydroxypyrrolidin-2-yl)-Hydroxamate Et Leurs Procédés D'Utilisation
摘要:本公开涉及双功能化合物,可用作靶向泛素化的调节剂.具体而言,本公开涉及包含一端为vhl配体基团的化合物,该基团结合vhl E3泛素连接酶,另一端含有结合靶蛋白的基团,从而实现对靶蛋白/多肽的降解.还公开了vhl配体.