2-溴苯胺 以90%的收率获得邻溴氟苯 参考文献:Process For The Preparation Of Fluoroaromatic And Fluoroheteroaromatic Compounds 标题:Process For The Preparation Of Fluoroaromatic And Fluoroheteroaromatic Compounds
专利信息
专利号:US-6995289-B2 优先权日:2000-08-02 标题 :Process for synthesis of alpha, beta-unsaturated ketones 发明人:PATEL IAN; HOPES PHILIP 权利人:ASTRAZENECA AB 摘要:A method for the synthesis of an α,β-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The α,β-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-2007238878-A1 优先权日:2004-10-13 标 题 :Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines 发明人:DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R 权利人:DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R 摘要:The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)-piperidines of the Formula (VI), and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the Formula (VII) or Formula (VIII), to give a compound of the Formula (IX) or Formula (X) respectively, followed by catalic reduction of the compound of the Formula (IX) or dehydration of compound of formula (X) to give a compound of Formula (IX) followed by catalytic reduction of the compound formula (IX) to give the compound of the Formula (VI).
专利号:US-2024101516-A1 优先权日:2021-01-20 标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides 发明人:KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND 权利人:BASF SE 摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.
专利号:US-9365494-B2 优先权日:2008-12-18 标 题 :Process for synthesis of amino-methyl tetralin derivatives 发明人:DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN 权利人:DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN; ROCHE PALO ALTO LLC 摘要:Methods for producing a compound of formula k1 or k2 n nby reducing a dihydronapthalene amide compound of formula in n nwith hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2n nRu(Z) 2 (L)  j1;n nRu(E)(E′)(L)(D)  j2;n nwherein m, n, Ar, Y, R 1 E, E′, D, Z and L are as defined herein.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
[参考文献]: Stephen J Fowler, Et Al. Surveillance For Lower Airway Pathogens In Mechanically Ventilated Patients By Metabolomic Analysis Of Exhaled Breath: A Case-Control Study. Thorax. 2015 Apr;70(4):320-5.
合成参考文献
摘要:Amatore, M.; Aubert, C.; Malacria, M.; Petit, M., Science of Synthesis Knowledge Updates, (2012) 3, 99. 摘要:Vrána, J.; Růžička, A., Science of Synthesis Knowledge Updates, (2021) 2, 36. 摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 113. 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Gao, W.-C.; Tian, J., Science of Synthesis Knowledge Updates, (2020) 3, 292.