CAS: 109-69-3; 1-Chlorobutane

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CAS号71-36-3 正丁醇 | CAS号6940-78-9 1-溴-4-氯丁烷 | CAS号109-65-9 正溴丁烷 | CAS号592-34-7 氯甲酸正丁酯 | CAS号75-44-5 光气 | CAS号807292-23-5 vinylphosphonic... | CAS号10026-13-8 五氯化磷 | CAS号2449-19-6 Boronic acid, 1... | CAS号7330-44-1 dibutoxy-(3-dib... | CAS号110-56-5 1,4-二氯丁烷 | CAS号105442-63-5 1-ethenyltellan... | CAS号120569-65-5 divinyl methyl ... | CAS号63000-06-6 ethenyltellanyl... | CAS号105797-57-7 2-butylselanyle... | CAS号105163-71-1 4-(2-butylsulfa... | CAS号10557-66-1 dibutylphosphor... | CAS号10519-06-9 1-butoxy-4-meth... | CAS号544-40-1 二丁基硫醚 | CAS号629-45-8 二丁基二硫醚 | CAS号109-79-5 正丁硫醇

氯甲酸丁酯置于hexabutylguanidinium Chloride体系中,化学反应 0.05H,以100%的收率获得氯丁烷
参考文献:六丁基胍氯化铵催化分解烷基氯甲酸酯
标题:六丁基胍氯化铵催化分解烷基氯甲酸酯
摘要:六丁基胍氯化物(0.5摩尔%)可以通过取代基效应和不对称氯化物合成证明的s N 2机理,将烷基氯甲酸酯有效地分解为氯化物,且烯烃形成率低.
Doi:10.1016/s0040-4039(97)00626-6

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-10711138-B2
优先权日:2016-04-08
标题:Intermediates and procedures for the synthesis of functional materials
发明人：KIRSCH PEER; GUNST SUSANN
权利人:MERCK PATENT GMBH
摘要:The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.

专利号:US-9012625-B2
优先权日:2009-04-07
标 题 :Method for the synthesis of a trisaccharide
发明人：DÉKANY GYULA; à GOSTON Kà ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVà CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS
权利人:DÉKANY GYULA; à GOSTON Kà ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVà CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS; GLYCOM AS
摘要:The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.

专利号:US-4749806-A
优先权日:1984-12-28
标题:Process for the synthesis of isocyanates and of isocyanate derivatives
发明人：TKATCHENKO IGOR; JAOUHARI RABIH; BONNET MICHEL; DAWKINS GORDON; LECOLIER SERGE
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of isocyanates and of isocyanate derivatives. Isocyanates are obtained by reacting an organic halide with a metal cyanate in an organic medium in the presence of a catalyst consisting of a complex of nickel with at least one organic ligand, in which complex the nickel is in the zero oxidation state. A carbamate or a urea, respectively, are obtained by a subsequent reaction with a hydroxy compound or a primary or secondary amine. Isocyanates and their derivatives are used especially either as refined synthesis agents for the production of pesticides and medications, or as monomers or comonomers for the preparation of many macromolecular compounds.

专利号:US-2024082435-A1
优先权日:2021-02-26
标 题 :Solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates and their use as precursors for therapeutic and/or diagnostic agents
发明人：PINTO ARTUR; BONTEMPS ALEXIS; LEMAIRE LUCAS
权利人:TELIX INT INNOVATIONS PTY LTD
摘要:The disclosure provides methods for the solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates. The disclosure also relates to key intermediates of this process and methods for their preparation such as a method of preparing a compound of formula (V). Also disclosed are use of the conjugates as precursors for therapeutic and/or diagnostic agents, including treating and diagnosing prostate cancer.

专利号:US-9724673-B2
优先权日:2011-06-30
标 题:Supported alkoxylated organotin reactant, preparation and use for heterogeneous-phase synthesis of tetrazoles
发明人：LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE
权利人:LE GROGNEC ERWAN; QUINTARD JEAN-PAUL; KERRIC GAELLE; CHRETIEN JEAN-MATHIEU; ZAMMATTIO FRANCOISE; UNIV NANTES; CENTRE NAT RECH SCIENT
摘要:A supported alkoxylated organotin reactant, to the process for preparing same, to the use of such a reactant as a catalyst for heterogeneous-phase organic synthesis, and also to a process for heterogeneous-phase synthesis of 5-substituted or 1,5-disubstituted tetrazoles using such a reactant.