乙二醇 反应生成二乙二醇乙醚 参考文献:Lotxov,V. A.;Landa,I. V.;Malyusov,V. A.;Kulov,N. N.,14 Mendeleev. Sezd Po Obshch. I Prikl. Ximii,M.,(1989) S. 284 标题:Lotxov,V. A.;Landa,I. V.;Malyusov,V. A.;Kulov,N. N.,14 Mendeleev. Sezd Po Obshch. I Prikl. Ximii,M.,(1989) S. 284
专利号:WO-2023012709-A1 优先权日:2021-08-05 标 题 :An improved process for fmoc synthesis of semaglutide 发明人:LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN 权利人:USV PRIVATE LTD 摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.
专利号:US-5905091-A 优先权日:1996-07-03 标 题 :Enhancement of skin pigmentation by prostaglandins 发明人:FULLER BRYAN B 权利人:UNIV OKLAHOMA 摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.
专利号:US-7855287-B2 优先权日:2007-01-24 标题 :Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity 发明人:DELLA CIANA LEOPOLDO 权利人:CYANAGEN SRL 摘要:A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler, more direct, and more efficient than the procedures currently used for the synthesis of N-alkylsulfonates derivatives of phenothiazine. In addition, the products obtained with this process are far more pure than those obtained through current procedures and therefore ideal for bioanalytical applications that require high sensitivity, such as assays based on the measurement of peroxidase activity using chemiluminescence.
专利号:US-4243787-A 优先权日:1977-11-23 标 题 :Bulk anionic polymerization process using an alkali metal amide and the salt of the same alkali metal with a hydroxylic compound 发明人:BOILEAU SYLVIE L; CAUBERE PAUL J; NDEBEKA GILBERTE; LECOLIER SERGE L; RAYNAL SERGE F 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The invention relates to a process for the anionic polymerization and copolymerization of vinyl, dienic and heterocyclic monomers. According to the invention, the process consists in carrying out the reaction in the presence of an initiator consisting of a molecular combination of an alkali metal amide and the salt of the same alkali metal with at least one hydroxylic compound and in the absence of solvent. The initiator can be prepared by intimately mixing its constituents or in the presence of a solvent of low polarity which is subsequently evaporated off, or in situ in the monomer. Application to the synthesis of special or widely used polymers and copolymers.
专利号:US-2005209355-A1 优先权日:2004-03-22 标 题:[Novel Reactions and the Products of Such Reactions] 发明人:ROITMAN LIPA L 权利人:ROITMAN LIPA L 摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.
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合成参考文献
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