CAS: 1823-91-2; 2-Phenylpropanenitrile

上下游产品

CAS号34713-70-7 2-苯基丙醛 | CAS号1617-17-0 2-氯丙腈 | CAS号368-47-8 苯基三氟硅烷 | CAS号292638-84-7 phenylene-ethylene | CAS号75-86-5 丙酮氰醇 | CAS号140-29-4 苯乙腈 | CAS号74-88-4 碘甲烷 | CAS号492-37-5 2-苯基丙酸 | CAS号1125-70-8 2-苯基丙酰胺 | CAS号672-65-1 1-氯-1-苯乙烷 | CAS号2049-80-1 烯丙基丙二酸二乙酯 | CAS号3195-24-2 二烯丙基丙二酸二乙酯 | CAS号5591-70-8 3-氨基-4-苯基-1H-吡唑 | CAS号50712-63-5 2-(4-硝基苯基)丙腈 | CAS号34298-25-4 (R)-beta-甲基苯乙胺盐酸盐 | CAS号5961-33-1 3-甲基-3-苯基氮杂啶 | CAS号1425-59-8 2-Methyl-2-phen... | CAS号492-37-5 2-苯基丙酸 | CAS号7782-24-3 (|S|)-(+)-2-苯丙酸 | CAS号7782-26-5 R-2-苯基丙酸

2-Phenylpropanamide置于光气体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 4.0H,以82%的收率获得α-甲基苯腈
参考文献:从相应的酰胺或腈合成 1-芳基-2-氨基链烷醇衍生物的一锅法
标题:从相应的酰胺或腈合成 1-芳基-2-氨基链烷醇衍生物的一锅法
摘要:我们已经确定了一种用于合成 β-氨基醇的新型一锅法,该方法基于苄基 α-碳原子上的 C-H 键羟基化,随后腈或酰胺官能团还原.这种级联过程使用分子氧作为氧化剂和双(2-甲氧基乙氧基)氢化铝钠作为还原剂.对 30 个条目检查了底物范围,尽管相应产品仅以中等产率提供,但上述简单方案可作为其他难以制备的空间拥挤 1,2-氨基醇的直接且有力的入口路线.给出了观察结果的合理机械原理,并将反应应用于潜在生物活性靶标的合成.
Doi:10.1039/d0Ra04359A

专利信息

专利号:WO-2014202765-A1
优先权日:2013-06-21
标题 :Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
发明人：STAVBER GAJ; GAZIC SMILOVIC IVANA; CLUZEAU JEROME; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.

专利号:US-6048991-A
优先权日:1990-11-16
标题:Preparation of epoxides
发明人：HAERMELING DIETER
权利人:BASF AG
摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.

专利号:US-7605290-B2
优先权日:2006-07-26
标题 :Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; SHENKAR NATALIA; SHACHAN-TOV SHARONA
权利人:TEVA PHARMA
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009069601-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2008221356-A1
优先权日:2006-07-26
标题:Processes for the synthesis of O-desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.

专利号:US-2009137846-A1
优先权日:2006-07-26
标题 :Processes for the synthesis of O-Desmethylvenlafaxine
发明人：NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
权利人:NIDDAM-HILDESHEIM VALERIE; NIDAM TAMAR; DOLITZKY BEN-ZION; FRENKEL GUSTAVO
摘要:The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.