CAS: 26021-57-8; 3,4-Dihydro-2H-Benzo[b][1,4]Oxazin-6-Ol

上下游产品

CAS号53412-38-7 6-羟基-2H-1,4-苯并嗪... | CAS号28226-20-2 2-氨基-1-(2,5-二甲氧... | CAS号102-56-7 2,5-二甲氧基苯胺

2-氯-N-(2,5-二甲氧基苯基)乙酰胺置于硼烷四氢呋喃络合物,三溴化硼,Sodium Hydride体系中,用 四氢呋喃,二氯甲烷,Mineral Oil 用作溶剂,化学反应 24.0H,反应生成羟苯并吗啉
参考文献: Oxazine-Based Fluorophore Compounds For Nerve-Specific Imaging[fr] Composés Fluorophores à Base D'Oxazine D'Imagerie Spécifique Du Nerf
标题: Oxazine-Based Fluorophore Compounds For Nerve-Specific Imaging[fr] Composés Fluorophores à Base D'Oxazine D'Imagerie Spécifique Du Nerf
摘要:这项发明涉及一种新型的氧杂噁嗪基荧光化合物,可用于体内神经成像,以及包含它们的组合物和使用方法.

专利信息

专利号:US-6887887-B2
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
发明人：BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER; SCHEINBERG DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: n n nwhere R 1 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine, said R 1 further comprising a cyclic or bicyclic structure; R 2 is methyl, CH 2 CH 3 , (CH 2 ) 2 CH 3 , C(CH 3 ) 3 , phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl; R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl; and R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH3) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine. Additionally, a method for the treatment of a neoplastic disease or for the inhibition of tumor cell growth each comprising the step of administering to an individual in need of such treatment a pharmacologically effective dose of the compounds of the present invention are provided.

专利号:US-2005272667-A1
优先权日:2001-03-19
标题:Analogs and derivatives of (S,S,R)-(-)-actinonin and uses therefor
发明人：SCHEINBERG DAVID; BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER
权利人:SCHEINBERG DAVID; BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER
摘要:The present invention provides analog and derivative compounds of (S,S,R)-(−)-actinonin and methods of asymmetric synthesis thereof having a structure: n n nwhere R 1 is hydrogen, C(O)R 6 or R 1 in combination with N is 2-oxomorpholine, R 2 is hydrogen, methyl, CH 2 CH(CH 3 ) 2 , (CH 2 ) 2 CH 3 , CH(CH 3 ) 2 , (CH 2 ) 3 CH 3 , (CH 2 ) 4 NH 2 , (CH 2 ) 3 CO 2 H, phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl, R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl, R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH 3 ) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine and R 6 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine where R 6 further comprising a cyclic or bicyclic structure. Also provided are methods for treating a neoplastic disease or for inhibiting tumor cell growth using the compounds present invention or using the compound (S,S,R)-(−)-actinonin.

专利号:US-2002198156-A1
优先权日:2001-03-19
标 题 :Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

专利号:US-2004019083-A1
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

专利号:US-6118008-A
优先权日:1996-05-03
标 题:Diamino pyrazols, their synthesis, keratin fibre dyeing compositions containing them, keratin fibre dyeing methods
发明人：MALLE GERARD; VIDAL LAURENT; BURANDE AGNES; MAUBRU MIREILLE
权利人:OREAL
摘要:The invention discloses new 5-substituted 3,4-diamino pyrazols, their methods of preparation, compositions for keratin fiber oxidation dyeing containing them as an oxidizing base, and the dyeing methods using same.

专利号:EP-1372692-A2
优先权日:2001-03-19
标 题:Asymmetric synthesis of (s, s, r)-(-)-actinonin and its analogs and uses therefor