CAS: 33403-97-3; 4-(Ethylaminomethyl)Pyridine

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CAS号54433-74-8 N-ethyl-1-pyrid... | CAS号872-85-5 4-吡啶甲醛 | CAS号1508-75-4 托吡卡胺 | CAS号2766-43-0 B°C-L-丝氨酸甲酯 | CAS号1508-75-4 托吡卡胺 | CAS号57322-50-6 N-乙基-N-(4-吡啶甲基)阿托胺

Ethyl-[1-Pyridin-4-Yl-Meth-(E)-Ylidene]-Amine置于sodium Tetrahydroborate体系中,用 乙醇 作为反应溶剂,化学反应 12.0H,以2.3 G的收率获得产物n-(4-吡啶甲基)乙胺
参考文献:碳11标记的氧嘌呤类似物的合成和评估,用于正电子发射断层扫描成像中周围器官中转运蛋白(18 Kda)的成像
标题:碳11标记的氧嘌呤类似物的合成和评估,用于正电子发射断层扫描成像中周围器官中转运蛋白(18 Kda)的成像
摘要:为了开发用于在外周器官中对tspo进行成像的pet配体,我们通过在前导化合物[11 C]中引入吡啶环代替苯环,设计了三种新颖的氧嘌呤类似物[11 C] 3A-C(logd:1.81-2.17).] 2(logd:3.48).通过使甘氨酸7与甲基吡啶胺4反应,然后水解并与二苯基磷酰基叠氮化物进行curtius重排,来合成用于放射合成的去甲基前体10.的甲基化10A-ç用甲基碘产生的未标记的化合物3A-ç.[的放射性合成11A] 3A-C通过使10A-C与[11 C]甲基碘反应来进行.化合物3A-C对tspo表现出较高或中等的体外结合亲和力(k I:5-40 Nm).大鼠中[11 C] 3A-C的pet表现出较高的肺,心脏和肾脏摄取,这些器官是高tspo表达的器官.[11 C] 3A的代谢物分析表明,这些器官中的放射性主要与未改变的[11 C] 3A相对应.pet
DOI:10.1021/jm200516A

专利信息

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:EP-1890995-A2
优先权日:2005-06-14
标 题:Synthesis of organic compounds

专利号:EP-3904354-A1
优先权日:2020-04-30
标 题:New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I)n nwherein R 1 represents a (C 1 -C 6 )alkyl group, a spiro(C 5 -C 11 )bicyclic ring, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherein L is either a single bond or a (Ci-C3)alkanediyl group, and R' represents a (C 3 -C 8 )cycloalkyl group, a bridged (C6-C 10 )cycloalkyl group, a (C 3 -C 8 )heterocycloalkyl group, or a (C 3 -C 8 )heteroaryl group, or a R'-L- group wherein L is a (Ci-C3)alkanediyl group, and R' is a an optionally substituted phenyl group or any of its pharmaceutically acceptable salt. n The present invention further relates to a composition comprising a compound of formula (I) and a process for manufacturing said compound as well as its synthesis intermediates. n It also relates to said compound for use as a medicament, in particular in the treatment and/or prevention of cognitive deficits associated with Down syndrome; Alzheimer's disease; dementia; tauopathies; Parkinson's disease; CDKL5 Deficiency Disorder; Phelan-McDermid syndrome; autism; diabetes; regulation of folate and methionine metabolism; osteoarthritis; Duchenne muscular dystrophy; several cancers; neuroinflammation, anemia and infections and for regulating body temperature.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:WO-0050406-A1
优先权日:1999-02-22
标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAEL
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.