CAS: 34582-32-6; Boc-Asp-Otbu

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Boc-L-天冬氨酸 4-苄酯置于palladium 10% On Activated Carbon,三氟化硼乙醚,氢气体系中,用 乙醇,二氯甲烷,环己烷 作为反应溶剂,20.0 °C,344.75 Kpa 条件下,反应 5.0H,反应生成 N-叔丁氧羰基-L-天冬氨酸 1-叔丁酯
参考文献:光学纯 4-氟-谷氨酰胺的合成作为潜在的肿瘤代谢成像剂
标题:光学纯 4-氟-谷氨酰胺的合成作为潜在的肿瘤代谢成像剂
摘要:通过利用 Passerini 三组分反应开发了一种用于制备所有四种立体异构 4-氟-谷氨酰胺的通用合成路线.有效构建了 4-取代谷氨酰胺衍生物的骨架.随后的四步反应,以"中和"的 Tasf 氟化为重点,提供了具有高产率和优异光学纯度的所需产物.使用 18-Crown-6/khco(3) 或 K[222]/k(2)Co(3) 催化系统也成功地制备了光学纯氟 18 标记的 4-氟谷氨酰胺.使用 9L 肿瘤细胞和 Sf188(Bcl-Xl) 肿瘤细胞(一种源自胶质母细胞瘤的谷氨酰胺成瘾肿瘤)进行的初步细胞摄取和抑制研究为它们与正电子发射断层扫描 (Pet) 结合用于体内成像的潜在应用提供了强有力的证据.肿瘤,
DOI:10.1021/ja109203D

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

专利号:CN-117165967-A
优先权日:2023-09-01
标题 :A method for photoelectrochemical synthesis of alkenyl-containing unnatural amino acid derivatives

专利号:WO-2024097744-A2
优先权日:2022-11-01
标题 :Dna-compatible wittig olefination of on-dna peptidyl-ylides for development of on-dna peptidomimetics through diversity-oriented synthesis (dos)

专利号:WO-9932453-A1
优先权日:1997-12-22
标 题:POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS
发明人：AUDIA JAMES E; MABRY THOMAS E; NISSEN JEFFREY S; MCDANIEL STACEY L
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; MABRY THOMAS E; NISSEN JEFFREY S; MCDANIEL STACEY L
摘要:Disclosed are polycyclic α-amino-⊂-caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of β-amyloid peptide release and/or its synthesis.

专利号:CN-108264538-A
优先权日:2017-01-04
标题 :Solid Phase Synthesis Method of Aspartic Acid Condensate