CAS: 36823-88-8; 4-(Trifluoromethoxy)Benzoyl Chloride

相似化合物

659-28-9 73960-07-3 85013-98-5

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CAS号330-12-1 4-(三氟甲氧基)苯甲酸 | CAS号456-71-3 4-(三氟甲氧基)苯甲酰胺 | CAS号897656-36-9 N-methoxy-N-met...

4-三氟甲氧基苯甲酸甲酯置于草酰氯体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-(三氟甲氧基)苯甲酰氯
参考文献:鉴定和优化 3-溴-N'-(4-羟基苯亚甲基)-4-甲基苯甲酰肼衍生物作为 Mtor 抑制剂,在三阴性乳腺癌中诱导自噬细胞死亡和凋亡
标题:鉴定和优化 3-溴-N'-(4-羟基苯亚甲基)-4-甲基苯甲酰肼衍生物作为 Mtor 抑制剂,在三阴性乳腺癌中诱导自噬细胞死亡和凋亡
摘要:三阴性乳腺癌(tnbc)由于其特殊的生物学行为和临床病理特征,其预后比其他类型的乳腺癌更差.tnbc 细胞增殖和进展到转移可以通过诱导细胞抑制自噬来抑制.mtor与自噬密切相关,参与蛋白质合成,营养代谢,激活mtor促进肿瘤生长和转移.在本文中,我们采用结构简化的策略,旨在通过基于药效团的虚拟筛选和生物活性测定寻找新型 Mtor 小分子抑制剂.我们发现了一种先导化合物 3-溴-N'-(4-羟基亚苄基)-4-甲基苯甲酰肼,用于合理的药物设计和结构修饰,然后研究了其构效关系.之后,复合获得了具有最佳tnbc细胞抑制活性和优越mtor酶抑制活性的7C.此外,我们发现化合物7C可以在mda-Mb-231和mda-Mb-468细胞系中诱导自噬细胞死亡和凋亡.总之,这些发现为我们的 3-溴-N'-(4-羟基亚苄基)-4-甲基苯甲酰肼衍生物提供了新的线索,有望成为未来治疗 Tnbc 的候选药物.
DOI:10.1016/j.Ejmech.2021.113424

专利信息

专利号:US-2005234244-A1
优先权日:2004-04-20
标题:Synthesis of COX-2 and FAAH inhibitors
发明人：BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
权利人:BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
摘要:Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:US-4665074-A
优先权日:1984-05-10
标 题:6-(polyfluoroalkoxyphenyl) pyridazinones, their compositions, synthesis and use
发明人：AMSCHLER HERMANN
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:6-aryl-3[2H]pyridazinones of formula I (I) in which one of the substituents R1 and R2 denotes hydrogen or (C1-C4)-alkoxy, and the other denotes polyfluoro-(C1-C4)-alkoxy, and their pharmacologically-tolerated salts are suitable as bronchospasmolytic and cardiotonic active compounds. Processes for their preparation and appropriate medicaments are indicated.

专利号:WO-2006050120-A2
优先权日:2004-11-01
标题:Synthesis of cox-2 and faah inhibitors

专利号:US-2008176857-A1
优先权日:2005-03-25
标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:RU-2194044-C2
优先权日:1997-10-01
标 题 :Derivatives of benzamidine, method of their synthesis and pharmaceutical composition