CAS: 39809-25-1; 2-Amino-9-(4-Hydroxy-3-(Hydroxymethyl)Butyl)-1H-Purin-6(9H)-One

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CAS号97845-59-5 6-chloro-9-[2-(... | CAS号97845-60-8 9-[4-乙酰氧基-3-(乙酰... | CAS号234110-23-7 dimethyl 2-[2-(... | CAS号7459-46-3 1,1,2-乙烷三羧酸三乙酯 | CAS号6482-32-2 2-羟甲基-1,4-丁二醇 | CAS号102147-75-1 2-(2,2-dimethyl... | CAS号97845-58-4 5-(2-溴乙基)-2,2-二... | CAS号118-00-3 鸟苷 | CAS号206067-84-7 6H-嘌呤-6-酮 | CAS号97845-60-8 9-[4-乙酰氧基-3-(乙酰... | CAS号104227-86-3 泛昔洛韦USP相关物质A | CAS号104227-87-4 泛昔洛韦 | CAS号97845-74-4 [4-(2-amino-6-o... | CAS号97845-75-5 [4-(2-amino-6-o...

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-7205128-B2
优先权日:2002-08-16
标题:Method for synthesis of the second strand of cDNA
发明人：ILSLEY DIAN D
权利人:AGILENT TECHNOLOGIES INC
摘要:Synthesis of the second strand of cDNA using pol âˆ?-primase is provided. Pol âˆ?-primase is used to initiate primers on a cDNA strand de novo, followed by extension of the primer with pol âˆ?-primase, a second DNA polymerase or a combination thereof. In a preferred embodiment, pol âˆ?-primase extends the primer, followed by addition of a second DNA polymerase, preferably Klenow fragment.

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人：LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-2016185745-A1
优先权日:2013-08-07
标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
发明人：SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM
权利人:UNIV TEXAS
摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.