CAS: 43212-41-5; 2,4-Dichloro-6-Methoxypyrimidine

相似化合物

26452-81-3 22536-63-6 13223-25-1

上下游产品

CAS号29458-38-6 6-甲基嘧啶-2,4(1H,3H)-二酮 | CAS号3764-01-0 2,4,6-三氯嘧啶 | CAS号124-41-4 甲醇钠 | CAS号67-56-1 甲醇 | CAS号6320-15-6 2,4-二甲氧基-6-氯嘧啶 | CAS号5734-64-5 2-氨基-4-氯-6-甲氧基嘧啶 | CAS号6104-41-2 4-甲氧基嘧啶 | CAS号155-90-8 2-氨基-4-甲氧基嘧啶

2,4,6-三氯嘧啶 以 四氢呋喃,2,3,5-三甲基吡啶,甲醇 作为反应溶剂,化学反应生成 2,4-二氯-6-甲氧基嘧啶
参考文献:Pharmaceutically Active Amines
标题:Pharmaceutically Active Amines
摘要:芳香胺(i),烷基胺(II),双环胺(iii),环烷基胺(iv),芳香双环胺(v),氢醌胺(vi),醌胺(vii),氨基醚(viii)和双环氨基醚(ix)可用作治疗多种疾病的药物,包括脊椎创伤,轻微和/或中度至严重头部损伤等.还公开了一种使用3,4-二氢苯并吡喯(xi)的治疗方法.

专利信息

专利号:WO-2025026392-A1
优先权日:2023-08-02
标题 :Kinesin kif18a inhibitor and use thereof
发明人：XIAO YISONG; LAI KUNMIN; GU XIAOHUI; WANG MINGHUA; DENG JIACHEN; HU MIN
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:A KIF18 inhibitor having a structure as shown in formula (I) and a synthesis method therefor. The compound can be used to adjust the KIF18A protein, thereby affecting a cell cycle and cell proliferation process for the treatment of cancer and cancer-related diseases. Further disclosed are a pharmaceutical composition containing the compound, and a method for the treatment of conditions associated with KIF18A activity.

专利号:WO-2025067239-A1
优先权日:2023-09-26
标 题 :Kinesin kif18a inhibitor, and application thereof
发明人：XIAO YISONG; GU XIAOHUI; LAI KUNMIN; WANG MINGHUA; HU MIN
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:A KIF18 inhibitor, and a synthesis method therefor, capable of adjusting a KIF18A protein, so as to affect cell cycle and cell proliferation processes, in order to treat cancers and cancer-related diseases. Also provided are a pharmaceutical composition including the KIF18 inhibitor compound, and a method for treating KIF18A activity-related conditions.