CAS: 461432-23-5; 4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)Benzene

上下游产品

CAS号461432-22-4 (5-溴-2-氯苯基)(4-乙... | CAS号107-06-2 1,2-二氯乙烷 | CAS号21739-92-4 5-溴-2-氯苯甲酸 | CAS号103-73-1 苯乙醚 | CAS号21900-52-7 5-溴-2-氯苯甲酰氯 | CAS号864070-18-8 4-(5-溴-2-氯苄基)苯酚

4'-溴乙酰苯胺置于盐酸,氢氟酸,Sodium Nitrite体系中,用 甲醇,水,乙酸乙酯 作为反应溶剂,化学反应 21.5H,反应生成 5-溴-2-氯-4'-乙氧基二苯甲烷
参考文献:一种降糖药达格列净的制备方法
标题:一种降糖药达格列净的制备方法
摘要:本发明公开一种降糖药达格列净的制备方法,该方法以4‑羟基苯甲醛为起始原料,经烷基化,羰基还原,氯代与对溴乙酰苯胺发生烷基化反应,重氮化,氯代得到达格列净中间体5‑溴‑2‑氯‑4'‑乙氧基二苯甲烷,然后将中间体与2,3,4,6‑四‑o‑三甲基硅基‑d‑葡萄糖酸内酯经缩合,醚化,脱甲氧基得到降糖药达格列净.本发明的工艺路线所用原料价格便宜易得,工艺容易实现工业化,所得最终产品纯度高;而且,本发明的工艺路线新颖,合成路线短,且反应中无危险复杂工艺,设备简单,操作简便,适合工业化生产.

专利信息

专利号:WO-2015177083-A1
优先权日:2014-05-19
标题 :STEREOSELECTIVE SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ß-C-ARYLGLUCOSIDES
发明人：ZUPANCIC BORUT; SELIC LOVRO; CUSAK ANJA; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The invention belongs to the fields of pharmaceutical industry, and particularly to an improved stereoselective synthesis of intermediate compounds for the preparation of gliflozins, for example canagliflozin or structurally similar gliflozins. Gliflozins, such as canagliflozin, dapagliflozin, empagliflozin, or ipragliflozin, inhibit the sodium-dependent glucose cotransporter 2 (SGLT2) in the kidney and as such are useful in the treatment of type-2 diabetes.

专利号:US-11565990-B2
优先权日:2020-12-04
标 题:Preparation of 4-bromo-2-(4′-ethoxyphenyl)-1-chlorobenzene
发明人：HU LIN; XU TAO; QIU XIAOLONG; LI XIAOYUE; ZUO ZHIWEI; LIU WENBO; CHU LINGLING; YUAN XIMENG; ZOU PING
权利人:WISDOM PHARMACEUTICAL CO LTD
摘要:A more environmentally friendly synthesis method of 4-bromo-2-(4′-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4′-ethoxyphenyl)-1-chlorobenzene.

专利号:EP-2947077-A1
优先权日:2014-05-19
标 题 :Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides

专利号:CN-114907396-A
优先权日:2022-05-11
标题 :A kind of method for continuous flow synthesis of Liejing drug intermediate

专利号:CN-117551153-A
优先权日:2023-12-06
标题 :A method for continuous reaction synthesis of dapagliflozin intermediates

专利号:CN-114907396-B
优先权日:2022-05-11
标 题 :A method for continuous flow synthesis of levofloxacin-type drug intermediates