CAS: 480-36-4; 5-Hydroxy-2-(4-Methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

CAS号771480-96-7 5-hydroxy-2-(4-... | CAS号520-27-4 地奥司明 | CAS号480-44-4 金合欢素； 刺槐素 | CAS号4154-21-6 acetone oxime h... | CAS号480-44-4 金合欢素； 刺槐素 | CAS号5128-44-9 5-羟基-4’,7-二甲氧基黄酮

地奥司明置于palladium On Activated Charcoal 甲酸铵,Potassium Hydrogencarbonate体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 7.0H,反应生成 蒙花苷
参考文献:Semisynthesis Of Linarin,Acacetin,And 6-Iodoapigenin Derivatives From Diosmin
标题:Semisynthesis Of Linarin,Acacetin,And 6-Iodoapigenin Derivatives From Diosmin
摘要:Semisynthesis Of Linarin And Acacetin From The Citrus Flavonoid Diosmin Was Performed Via,As First Intermediate,The 3'-O-Phenyltetrazolyl Ether Of Diosmin. This Paper Relates Also A Semisynthetic Access To 6-Iodoapigenin Derivatives,Which Are Key Compounds In The Synthesis Of Some Biflavonoids Such As Robustaflavone.
DOI:10.1021/np040079B

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:FR-3002543-A1
优先权日:2013-02-28
标题:METHOD FOR THE ENZYMATIC SYNTHESIS OF FLAVONOIDS AND APPLICATION TO THE SYNTHESIS OF DIOSMETIN DERIVATIVES

专利号:US-2025231101-A1
优先权日:2024-01-11
标 题 :Validation of natural matrices for therapeutic use on humans, animals and plants on bio-physical bases as an alternative to validation through chemically definable substances derived from said matrices by isolation and/or synthesis processes and also as an alternative to products comprising natural matrices validated on the basis of their traditional use
发明人：MERCATI VALENTINO; LUCCI JACOPO
权利人:BIOS THERAPY PHYSIOLOGICAL SYSTEMS FOR HEALTH S P A
摘要:The present invention relates to a new method for assessing acceptability ranges or cut-offs for the compliance validation of batches of products comprising or consisting of one or more natural matrix, wherein said products have an ascertained therapeutic or beneficial effect. The invention also relates to a new process for the compliance validation of one or more batches of said products.

专利号:US-2023000758-A1
优先权日:2021-06-25
标题 :Method for preventing skin aging comprising korean mint extract
发明人：YOO JIN HEE; CHOI SU YOUNG; YUN WON IL
权利人:COSMAX NBT INC; COSMAX NS INC
摘要:Provided are a method for preventing or treating photoaging of skin, including: administering a composition comprising an effective amount of an extract of Agastache rugosa O Kuntze to a subject in need thereof. The composition decreases expression of matrix metalloproteinases (MMPs) induced by ultraviolet B (UVB) irradiation; decreases expression of mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling; improves collagen synthesis; decreases skin inflammation induced by NF-κB; and decreases oxidative stress induced by UVB irradiation.

专利号:CN-113666887-B
优先权日:2021-09-18
标 题 :A kind of 1,4-naphthoquinone derivative, synthesis method and application