专利号:WO-2018193463-A1 优先权日:2017-04-21 标题 :An improved process for the preparation of tetrahydroisoquinoline compounds 发明人:DALVI MAHESH BHAGOJI; KENNY RAJESH SHASHIKANT; PATIL AJIT AAPPA; PALKAR TUSHAR TANAJI 权利人:NEON LABORATORIES LTD 摘要:The present invention discloses an improved process for preparation of substantially pure pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7- dimethoxy-1H-isoquinoline-2-propionate), a compound of formula I and its acid addition salts in good yields. Pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4- dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate) or its acid addition salts is the key intermediate for the synthesis of a non-depolarizing neuromuscular-blocking drugs. The process can also be used for the synthesis of various tetrahydroisoquinoline derivatives.
专利号:US-8034982-B2 优先权日:2007-04-11 标 题 :Isotopically tagged synons from 2 carbon precursors 发明人:MARTINEZ RODOLFO A 权利人:NEW MEXICO HIGHLANDS UNIVERSITY 摘要:The use of vinyl sulfides, sulfoxides and sulfones in synthetic chemistry for the production of a wide variety of materials is well known. For example, phenyl vinyl sulfides, sulfoxides and sulfones have been used for the synthesis of important heterocycles, in combinatorial chemistry and as Diels-Alder adducts. Although these compounds have been used extensively for a variety of applications, the isotopically labeled versions have not been reported. A simple route for the isotopically labeled production of these important building blocks has been developed.
专利号:US-3516802-A 优先权日:1960-11-21 标 题 :Continuous process for the synthesis of difluoramine 发明人:LOVETT JOHN R; SCHMALL EDWIN A 权利人:EXXON RESEARCH ENGINEERING CO