CAS: 52817-12-6; 6-Bromo-4-Oxo-4H-Chromene-3-Carbaldehyde

上下游产品

5-Bromo-2-hydroxyacetophenone N,N-dimethyl-formamide 4-bromo-phenol 4-bromophenyl acetate H-imidazol-2-yl)-chromen-4-one6-bromo-3-(4,5-diphenyl-1H-imidazol-2-yl)-chromen-4-one (2-Amino-pyrimidin-5-yl)-(5-bromo-2-hydroxy-phenyl)-methanone thiadiazepine7-(5'-bromo-2'-hydroxybenzoyl)-3-phenyl-1,2,4-triazolo3,4-b1,3,4thiadiazepine 1-[5-(5-Bromo-2-hydroxy-benzoyl)-2-methyl-pyridin-3-yl]-ethanone

2-羟基-5-溴苯乙酮置于三氯氧磷体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 6-溴-3-甲酰色酮
参考文献:通过铜双(恶唑啉)催化的 [4 + 2] 环加成对映选择性获得四氢氧蒽酮
标题:通过铜双(恶唑啉)催化的 [4 + 2] 环加成对映选择性获得四氢氧蒽酮
摘要:通过铜双(恶唑啉)催化的 Chrom-4-One 亲二烯体和 Danishefsky 的二烯的 [4 + 2] 环加成反应,实现了对四氢氧杂蒽酮化合物的高度对映选择性.含四元立构中心的氧代二氢氧吨酮(烯酮)加合物的产率高达 98%,Ee 高达 89%.环加合物用于合成四氢氧吨酮,具有新型有机锡介导的 β-酮酯准 Krapcho 脱羧作用,并保留立体化学.tetrahydroxanthone 是多种生物相关饱和氧杂蒽酮的多功能中间体.
DOI:10.1021/acs.Orglett.3C00612

专利信息

专利号:US-2012316192-A1
优先权日:2011-06-09
标题:Substituted indolo [2,3-a] quinolizines
发明人：WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
权利人:WALDMANN HERBERT; KUMAR KAMAL; HUEBEL KATJA; PRIES VERENA; DUECKERT HEIKO; MENNINGER SASCHA; ZIEGLER SLAVA; BRUSS HANNA; KHEDKAR VIVEK; ESCHENBRENNER VINCENT
摘要:The present invention relates to novel substituted indolo[2,3-a]quinolizines and stereoisomeric forms thereof and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these substituted indolo[2,3-a]quinolizines together with pharmaceutically acceptable carrier, excipient and/or diluents. Said novel substituted indolo[2,3-a]quinolizines have been identified as useful for the prophylaxis and treatment of cancer by the induction of strong mitotic delays, chromosomal misalignments and mitotic tri- and multipolarization leading to cell cycle stop and apoptosis. Furthermore a synthesis for preparation of the substituted indolo[2,3-a]quinolizines is disclosed in the present invention.

专利号:CN-114790213-A
优先权日:2022-04-29
标题 :Synthesis method of spiro[indazole-isoxazole] derivatives applied to methoxyphenyl substituted chromone structure