CAS: 5962-42-5; 3-Phosphonopropanoic Acid

该化合物是一种有机磷酸化合物,其特点是三碳丙酸脊柱上有一个磷酸功能组,该化合物一般是一种白晶状固体,由于极性,可溶于水中,可归因于磷酸组的极性,具有很强的酸等特性,其酸值表明它有能力捐献质子以溶解. 3-phosopropoprociencial酸在各个领域,包括生物化学和农业领域都有意义,因为它可以作为除草剂或生化剂,其结构允许它参与各种化学反应,使其成为有机合成的有用中间体.此外,由于它能够与生物系统互动,它可能具有开发药品和农用化学剂的应用.在处理和储存方面,应参考安全数据,如任何化学物质.

结构式图片

相似化合物

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欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

  • 合成目标产物 3-Phosphonopropionic Acid 主要起始原料 Triethyl 3-Phosphonopropionate
  • (文献来源)合成步骤主要原料 Triethyl 3-Phosphonopropionate
3-(Dibutoxyphosphoryl)Propanenitrile置于盐酸体系中,化学反应生成 2-羧乙基磷酸
参考文献:Kreutzkamp; Schindler,Archiv Der Pharmazie,1962,Vol. 295 /67,P. 28-33
标题:Kreutzkamp; Schindler,Archiv Der Pharmazie,1962,Vol. 295 /67,P. 28-33

海关参考信息

专利信息


专利号:US-5162566-A
优先权日:1991-08-26
标 题 :Stereospecific synthesis of tetrasubstituted acrylic esters
发明人:MATHEW JACOB
权利人:MALLINCKRODT SPEC CHEM
摘要:Substantially stereospacific (E)-tetrasubstituted acrylic esters, such as (II) where R is hydrogen alkyl, R1 is alkyl, aryl or aralkyl, R2 and R4 are alkyl, are formed from racemic mixtures of corresponding unsaturated esters and cuprates of the formula (R3)2CuX, wherein R3 is alkyl, aryl or aralkyl, and X is lithium or magnesium halide.

专利号:US-7973109-B2
优先权日:2007-03-29
标 题 :Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution
发明人:OGATA SHIN-ICHI; FUKUSHIMA YOSHIAKI; KAWASUMI MASAYA
权利人:TOYOTA CHUO KENKYUSHO KK
摘要:A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above.

专利号:US-7511113-B2
优先权日:2002-04-26
标题:Oligomeric hydroxy arylether phthalonitiles and synthesis thereof
发明人:KELLER TEDDY M; DOMINGUEZ DAWN D
权利人:US NAVY
摘要:An aromatic ether oligomer or polyaromatic ether comprising the formula:n n O—Ar n ;n nwherein Ar is an independently selected divalent aromatic radical; formed by reacting a dihydroxyaromatic with a dihaloaromatic; and wherein the reaction is performed in the presence of a copper compound and cesium carbonate. The polyaromatic ether is formed when neither the dihydroxyaromatic nor the dihaloaromatic is present in an excess amount. The aromatic ether oligomer is formed by using an excess of either dihydroxyaromatic or dihaloaromatic. A phthalonitrile monomer comprising the formula:n n nformed by reacting a 3- or 4-nitrophthalonitrile with a hydroxy-terminated aromatic ether oligomer. A thermoset formed by curing the phthalonitrile monomer. Processes for forming all the above.

专利号:US-2008050747-A1
优先权日:2006-03-30
标题:Articles having localized molecules disposed thereon and methods of producing and using same
发明人:KORLACH JONAS; TURNER STEPHEN
权利人:PACIFIC BIOSCIENCES CALIFORNIA
摘要:Sequencing methods and compositions, substrates, devices and systems are provided. Methods include synthesizing a nascent nucleic acid sequence that is greater than 100 bases in length and sequencing the nucleic acids by detecting synthesis. Compositions and substrates that include polymerization complexes for the methods are included.

专利号:WO-9925778-A1
优先权日:1997-11-14
标 题 :Synthesis and applications of intrinsically conductive polymer salts of polyphosphonic acids in anti-corrosion coatings
发明人:KINLEN PATRICK J; DING YIWEI; KONCKI KENNETH F
权利人:ZIPPERLING KESSLER & CO
摘要:A coating composition for protecting a corrodible metal suface from corrosion includes an intrinsically conductive salt of a polyphosphonic acid as well as a solvent and other optional components. The composition is used to form a protective coating on the surface of corrodible metals such as iron and steel. The coating passivates the metal surface and complexes the passivated metal, thus protecting the surface from rust and corrosion.

专利号:CA-2770695-A1
优先权日:2009-08-25
标题 :Synthesis of oxygen carrying, turbulence resistant, high density submicron particulates
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主要参考文献

[参考文献]: Charles E Mckenna, Et Al. Synthesis, Chiral High Performance Liquid Chromatographic Resolution And Enantiospecific Activity Of A Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-Imidazo[参考文献]: Kunio Ikemura, Et Al. Design Of A Metal Primer Containing A Dithiooctanoate Monomer And A Phosphonic Acid Monomer For Bonding Of Prosthetic Light-Curing Resin Composite To Gold, Dental Precious And Non-Precious Metal Alloys. Dent Mater J. 2011;30(3):300-7.
[参考文献]: Kunio Ikemura, Et Al. Effects Of A Newly Designed Hema-Free, Multi-Purpose, Single-Bottle, Self-Etching Adhesive On Bonding To Dental Hard Tissues, Zirconia-Based Ceramics, And Gold Alloy. Dent Mater J. 2011;30(5):616-25.
[参考文献]: M S Hasan, Et Al. Cytocompatibility Assessment Of Chemical Surface Treatments For Phosphate Glass To Improve Adhesion Between Glass And Polyester. J Biomed Mater Res A. 2013 Nov;101(11):3301-10.
[参考文献]: Serena Donnini, Et Al. Inclusion Of Ionization States Of Ligands In Affinity Calculations. Proteins. 2009 Jul;76(1):138-50.

合成参考文献


参考文献:10.4012/dmj.2010-163
摘要:Ikemura K, Fujii T, Negoro N, Endo T, Kadoma Y. Design of a metal primer containing a dithiooctanoate monomer and a phosphonic acid monomer for bonding of prosthetic light-curing resin composite to gold, dental precious and non-precious metal alloys. Dent Mater J. 2011;30(3):300–7. doi: 10.4012/dmj.2010-163.
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