2-Nitromalonamide置于aluminium Amalgam,氨体系中,化学反应生成 2-氨基丙二酰胺 参考文献:Researches On Hydantoins. Xxvii. Synthesis Of Hydantoin-4-Carboxamide. 标题:Researches On Hydantoins. Xxvii. Synthesis Of Hydantoin-4-Carboxamide. 摘要: DOI:10.1021/ja02179A015
专利号:US-7759497-B2 优先权日:2002-05-24 标 题:Synthesis of diaryl pyrazoles 发明人:LETENDRE LEO J; MCGHEE WILLIAM D; SNODDY CYNTHIA; KLEMM GEORGE; GAUD HENRY T 权利人:PFIZER 摘要:A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application.
专利号:US-7060818-B2 优先权日:2003-02-21 标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process 发明人:HORWITZ COLIN P; GHOSH ANINDYA 权利人:UNIV CARNEGIE MELLON 摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.
专利号:US-2004024225-A1 优先权日:2002-05-24 标题 :Synthesis of diaryl pyrazoles
专利号:US-2007004924-A1 优先权日:2002-05-24 标题:Synthesis of diaryl pyrazoles
专利号:US-3928347-A 优先权日:1968-11-08 标 题:Pyrazinylmalonic acid esters and salts and pyrazinylacetic acids, esters and salts 发明人:SCHWARTZ NORMAN; MOHRBACHER RICHARD J 权利人:MCNEILAB INC 摘要:The compound, 2,3-diphenyl-5-ethylpyrazine, useful as a precursor in the synthesis of those compounds of the class of pyrazine, arylpyrazine, diphenylpyrazine, and cycloalkylpyrazine malonates, acetates, acetamides, and acetic acids, useful for their ultraviolet light absorption properties.
专利号:US-2004167329-A1 优先权日:2003-02-21 标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process