118-69-4 = 6575-24-2 + 39652-34-1 + 83277-23-0 反应条件:1.1 Reagents: Sec-Butyllithium Solvents: Tetrahydrofuran,Cyclohexane; 45 Min,-75 °C1.2 Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified,25 °C 标题:Proton Mobility In 2-Substituted 1,3-Dichlorobenzenes: "Ortho" Or "Meta" Metalation? 作者:Schlosser,Manfred; Et Al 参考文献:European Journal Of Organic Chemistry 日期:2006 卷标:(19) 页码:4398-4404
2,6-二氯苯乙腈置于bradyrhizobium Japonicum (Q89Ge3),水体系中,化学反应生成 2,6-二氯苯乙酸 参考文献:A High-Throughput Screening Method For Determining The Substrate Scope Of Nitrilases 标题:A High-Throughput Screening Method For Determining The Substrate Scope Of Nitrilases 摘要:我们已经开发了一种显色试剂来显示腈酶活性,并展示了其在23种酶的细胞提取物中的应用. DOI:10.1039/c4Cc06021K
专利号:US-6528275-B1 优先权日:1996-04-24 标题:Substrates and inhibitors of proteolytic enzymes 发明人:QUIBELL MARTIN; JOHNSON TONY; HART TERANCE 权利人:MEDIVIR UK LTD 摘要:The present invention relates to the field of compounds which are substrates or inhibitors of proteolytic enzymes and to apparatus and methods for identifying substrates or inhibitors for proteolytic enzymes. We have devised a combinatorial method for the rapid indentification of binding motifs which will greatly expedite the synthesis of inhibitors of a variety of proteolytic enzymes such as aspartyl proteases, serine proteases, metallo proteases and cysteinyl proteases.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-7002020-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:DE-102012224021-A1 优先权日:2012-05-09 标 题 :A process for the synthesis of phenylacetic acid by carbonylation of toluene
专利号:JP-2013234166-A 优先权日:2012-05-09 标 题 :Synthesis of phenylacetic acid by carbonylation of toluene
参考文献:10.1126/sciadv.abf8711 摘要:Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT; QCRG Structural Biology Consortium, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci Adv. 2021 Apr;7(16). 摘要:Berlinck, R. G. S.; Kossuga, M. H.; Nascimento, A. M., Science of Synthesis, (2005) 18, 1097.