CAS: 113852-37-2; (S)-(((1-(4-Amino-2-Oxopyrimidin-1(2H)-yl)-3-Hydroxypropan-2-yl)Oxy)Methyl)Phosphonic Acid

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CAS号120362-35-8 (S)-1-[3-Hydrox... | CAS号120362-33-6 (S)-1-[3-(Benzy... | CAS号132336-37-9 (S)-N1-[(3-羟基-2... | CAS号132336-36-8 DIETHYL (((1-(4... | CAS号132336-35-7 (S)-diethyl (((... | CAS号71-30-7 胞嘧啶 | CAS号127757-45-3 cyclic-1-(3-hyd...

(S)-1-<3-Hydroxy-2-<(Diethylphosphonyl)Methoxy>Propyl>Cytosine 以88的收率获得西多福韦
参考文献:抗病毒药物西多福韦的一种合成方法
标题:抗病毒药物西多福韦的一种合成方法
摘要:抗病毒药物西多福韦的一种合成方法,属于抗病毒化学药物领域,本发明从原料(S)-羟甲基环氧乙烷出发,合成(S)-1-R-2,3-环氧丙烷(r为烃基),经醚化,酰化,縮合,脱保护基,水解,酸化等反应制备西多福韦.该合成工艺操作简单,成本低廉,收率高,纯度高,污染小,非常适合工业化生产.

专利信息

专利号:US-8278483-B2
优先权日:2006-02-07
标题:Process for synthesis of glycomimicking cationic amphiphiles
发明人：MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA
权利人:MAHIDHAR YENUGONDA VENKATA; CHAUDHURI ARABINDA; MUKHERJEE RAMA; COUNCIL SCIENT IND RES
摘要:The present invention provides processes for the synthesis of novel Shikimic acid head-group containing non-toxic cationic amphiphiles capable of facilitating transport of biological macromolecules into cells.

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人：LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-9862687-B2
优先权日:2013-11-15
标题:Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
发明人：WARE JR ROY WENDELL; DOWNEY AARON LEIGH
权利人:CHIMERIX INC; CHIMERIX INC
摘要:The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.