间羟基苯甲酸置于lithium Aluminium Tetrahydride,硫酸,Potassium Carbonate体系中,用 四氢呋喃,丙酮 用作溶剂,化学反应 36.17H,反应生成3-苯甲氧基苯甲醇 参考文献:Synthesis And Antifungal Properties Of Papulacandin Derivatives 标题:Synthesis And Antifungal Properties Of Papulacandin Derivatives 摘要:一种靶向β-(1,3)-D-葡聚糖合酶的抗真菌剂 Papulacandin D 的衍生物已合成并进行了活性测试.Papulacandin D 结构包含一个具有挑战性的苯环螺环糖醚单元,该单元是通过一种钯催化的糖环硅醇酸酯和芳基碘化物的交叉偶联反应引入的,随后进行氧化螺环糖醚化反应.制备了四种不同的变体,其在酰基侧链的性质,长度以及双键的数量和立体化学方面有所不同.基于棕榈酸和亚油酸的侧链的衍生物显示出中等生物活性. Doi:10.3762/bjoc.8.82
专利号:US-9884830-B2 优先权日:2004-05-21 标题 :Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; CHAREST MARK G; LERNER CHRISTIAN D; BRUBAKER JASON D; SIEGEL DIONICIO R 权利人:HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
专利号:US-8486921-B2 优先权日:2006-04-07 标 题:Synthesis of tetracyclines and analogues thereof 发明人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU 权利人:MYERS ANDREW G; BRUBAKER JASON D; SUN CUIXIANG; WANG QIU; HARVARD COLLEGE 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
专利号:US-7179918-B2 优先权日:2001-06-11 标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 发明人:CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD 权利人:AGOURON PHARMA 摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
专利号:US-2018230111-A1 优先权日:2004-05-21 标 题:Synthesis of tetracyclines and analogues thereof
专利号:US-8598148-B2 优先权日:2004-05-21 标题:Synthesis of tetracyclines and analogues thereof
专利号:US-2010130451-A1 优先权日:2006-04-07 标 题:Synthesis of tetracyclines and analogues thereof