(2S)-2,4-二({[(2-甲基-2-丙基)氧基]羰基}氨基)丁酸置于盐酸体系中,用89%的收率获得l-2,4-二氨基丁酸 单盐酸盐 参考文献:Preparation Of Enantiopure 2-Acylazetidines And Their Reactions With Chloroformates 标题:Preparation Of Enantiopure 2-Acylazetidines And Their Reactions With Chloroformates 摘要:Enantiopure 1-Phenylethylazetidine-2-Carboxylates And 2-Acylazetidines Were Prepared And Reacted With Chloroformates To Yield Alpha-Chloro-Gamma-Amino Butyric Acid Esters And Ketones From Ring Opening Reaction Of Azetidinium Ion Intermediate In A Completely Regio-And Stereoselective Manner. (C) 2006 Elsevier Ltd. All Rights Reserved. Doi:10.1016/j.Tetlet.2006.11.033
专利号:US-4234744-A 优先权日:1978-12-18 标 题 :Process for the production of aminoacid hydrochlorides/or diaminoacid dihydrochlorides 发明人:EFFENBERGER FRANZ; DRAUZ KARLHEINZ 权利人:DEGUSSA 摘要:Aminoacid hydrochlorides or diaminoacid dihydrochlorides are produced by first reacting a halocarboxylic acid ester with an alkali metal cyanate in the presence of an alcohol to form the corresponding mono- or diurethane and then saponifying this to the corresponding mono- or dihydrochloride. The new process is relatively versatile in its use and above all opens up an elegant synthesis route for lysine.
专利号:US-12227528-B2 优先权日:2017-11-09 标 题:Glucose-sensitive albumin-binding derivatives 发明人:KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA 权利人:NOVO NORDISK AS 摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.
专利号:CN-115612114-A 优先权日:2021-07-14 标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
参考标题:Synthesis Of Cyclic Amidines 摘要:The Invention Relates To An Innovative Method For Synthesis Of Cyclic Amidines. The Synthesis Starts From A β-, γ- Or δ-Lactone Which Is Twofold Brominated. After Esterification Of The Carboxyl Function, The Bromine Atoms Are Nucleophilically Substituted And The Corresponding Diamino Compound Is Obtained. The Ring Closure To The Cyclic Amidine Is Accomplished Subsequently By Reaction With Orthoester, Imidate Or Thioimidate. Owing To Interposing Additional Steps For Recovery Of The Diamino Compound In Enantiomerically Pure Form, The Enantiomers Of The Cyclic Amidines Can Be Stereoselectively Synthesized.
合成参考文献
参考文献:10.1007/s00216-014-7872-y 摘要:Combes A, El Abdellaoui S, Vial J, Lagrange E, Pichon V, BMAALS group. Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-l-alanine in brain tissues. Analytical and Bioanalytical Chemistry. 2014 May 25;406(19):4627–36. doi: 10.1007/s00216-014-7872-y.