CAS: 20358-02-5; 4-Bromobenzo[d]Thiazol-2-Amine

上下游产品

4-溴苯并噻唑 4-Bromobenzothiazole 767-68-0

2-溴苯胺盐酸盐置于盐酸,溴体系中,用 氯仿,水 用作溶剂,化学反应 4.5H,反应生成2-氨基-4-溴苯并噻唑
参考文献:合成的3-(1,3-苯并噻唑-2-基)2-苯基喹唑啉-4(3 H)-作为强效抗菌剂的qsar建模
标题:合成的3-(1,3-苯并噻唑-2-基)2-苯基喹唑啉-4(3 H)-作为强效抗菌剂的qsar建模
摘要:目前的通讯引发了作为潜在抗菌剂的3-(1,3-苯并噻唑-2-基)2-苯基喹唑啉-4(3 H)-One的设计和合成.[(-一个数字取代的2-苯并噻唑氨基的,2-氨基-5-ë)-苯基二氮烯基]苯甲酸,和2-苯基-4-ħ恶嗪-4-酮合成为苯并[d] [1,3]前体基板.这些化合物以极高的收率合成,并且根据ir,1证实了结构1 H NMR,质量和元素分析数据.体外筛选了这些化合物对革兰氏阳性和革兰氏阴性细菌代表菌群的抗菌活性,并通过定量结构-活性关系(qsar)建立了模型,并使用顺序回归程序确定了由于结构和取代作用而引起的活性贡献.抗菌测定数据表明,发现合成的化合物表现出深远的抗菌活性.
Doi:10.1007/s00044-011-9626-0

专利信息

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.

专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:CN-119977939-A
优先权日:2025-03-21
标题:Synthesis method of 1, 9-dihalogenated dibenzothiophene derivative