CAS: 33406-96-1; 1-Chloro-4-Fluoro-2-Methylbenzene

上下游产品

CAS号452-71-1 4-氟-2-甲基苯胺 | CAS号81778-09-8 2-氯-5-氟溴苄 | CAS号84194-30-9 2-氯-5-氟苯甲醛 | CAS号170098-88-1 1-氯-4-氟-2-甲基-5-硝基苯

4-氟-2-甲基苯胺置于盐酸,Sodium Nitrite,Copper(L) Chloride体系中,用 水 用作溶剂,化学反应 2.0H,以41%的收率获得2-氯-5-氟甲苯
参考文献:N-Sulfonyl Benzamide Derivative With Heterocyclic Substituent,Preparation Method Therefor And Pharmaceutical Application Thereof
标题:N-Sulfonyl Benzamide Derivative With Heterocyclic Substituent,Preparation Method Therefor And Pharmaceutical Application Thereof
摘要:本发明公开了一种具有杂环取代基的n-磺酰基苯甲酰胺衍生物,以及其制备方法和药物应用.更具体地,该发明公开了一种由化学式(II)表示的化合物或其药用可接受的盐,立体异构体,溶剂化合物或前药,以及其制备方法和应用.有关化学式中每个基团的定义,请参阅说明书.

专利信息

专利号:WO-2023143605-A1
优先权日:2022-01-31
标 题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents

专利号:US-9771356-B2
优先权日:2012-09-21
标题 :Inhibitors of beta-hydroxylase for treatment of cancer
发明人：WANDS JACK R; DE LA MONTE SUZANNE; AIHARA ARIHIRO; OLSEN MARK JON; THOMAS JOHN-MICHAEL
权利人:RHODE ISLAND HOSPITAL; UNIV MIDWESTERN
摘要:The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

专利号:EP-3210987-A1
优先权日:2007-08-06
标 题:Process for the synthesis of proteasome inhibitors