CAS: 4498-67-3; Indazole-3-Carboxylic Acid

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苯甲醛苯腙置于盐酸,溶剂黄146体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 6.0H,反应生成 吲唑-3-羧酸
参考文献:新型吲唑衍生物的合成分子对接和dft研究
标题:新型吲唑衍生物的合成分子对接和dft研究
摘要:酰胺键是一种重要的官能团,用于化学的各个领域,包括有机合成,药物发现,聚合物和生物学.尽管普通酰胺是平面的,并且酰胺具有 N-C(O) 键,但本文通过酰胺交叉偶联报道了 26 种吲唑衍生物 (8A-8Z).使用ir,1 H NMR,13 C NMR 和质谱分析所有产生的化合物.还使用 Gaussian 09-Gaussian View 6.1 进行了 Dft 计算研究,结果表明8A,8C和8S具有最大的 Homo-Lumo 能隙.通过使用 Autodock 4 对接衍生物来评估吲唑部分与肾癌相关蛋白 (Pdb: 6Few) 的有效性.分析表明衍生物8V,8W和8Y具有最高的结合能.
DOI:10.1039/d4Ra02151G

专利信息

专利号:RU-2190606-C2
优先权日:1997-11-04
标题:Methods of synthesis of 4-cyano-4-(substituted indazole)-cyclohexane carboxylic acid esters used as inhibitors of phosphodiesterase 4 (pde 4) and intermediate compounds for their synthesis

专利号:US-8598166-B2
优先权日:2008-03-21
标 题:Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; SANOFI SA
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 , Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:US-12122751-B2
优先权日:2019-06-25
标 题 :Processes of making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
发明人：JIAO XIANGDONG; KHUMTAVEEPORN KANJAI
权利人:TRANSLATUM MEDICUS INC
摘要:The invention in this disclosure is related to the processes of making Bindarit or derivatives thereof. Specifically, the present invention provides, in part, new processes for making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives. By way of non-limiting example, synthesis and purification processes of 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid are provided by the invention in this disclosure.

专利号:SU-679579-A1
优先权日:1978-02-16
标题:Chloranhydride of indazole-3-carbolic acid as intermediate product of synthesis of compositions of indazole series, and method of obtaining same

专利号:US-10087197-B2
优先权日:2012-05-21
标 题:Selective extraction of anions from solution
发明人：MEZEI GELLERT
权利人:WESTERN MICHIGAN UNIV RESEARCH FOUNDATION
摘要:A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, an optional counterion contributor, and at least one encapsulating anion to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [CuII(μ-OH)(μ-ea)]∞ and optionally, a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis-CuIIx(OR1)y(R2ea)z, where R1 is H or an alkyl group, R2 is H, or an alkyl group or a charged group, ea is an encapsulating anion, and each of x, y, and z is equal to an integer between about 1 and 40, inclusive. In addition, anion encapsulating aggregates can be formed by synthesis with alternate encapsulating anions by substituting alternate encapsulating anions for the encapsulating anion incorporated in the aggregate.