CAS: 501-52-0; 3-Phenylpropanoic Acid

上下游产品

CAS号122-97-4 3-苯丙醇 | CAS号621-82-9 肉桂酸 | CAS号103-41-3 肉桂酸苄酯 | CAS号79186-29-1 1,6-diphenyl-4-... | CAS号104-53-0 3-苯丙醛 | CAS号15814-45-6 allyl 3-phenylp... | CAS号124-38-9 二氧化碳 | CAS号103-63-9 β-溴苯乙烷 | CAS号140-10-3 肉桂酸 | CAS号69404-95-1 1-(tert-butyldi... | CAS号108976-70-1 2',5'-DIMETHYL-... | CAS号104822-00-6 chloromethyl 3-... | CAS号10264-23-0 Benzenepropanam... | CAS号100708-34-7 1-(3-iodopropyl... | CAS号10499-26-0 5-hydroxy-2,2,6... | CAS号107100-64-1 N-苯丙基-4-哌啶酮 | CAS号5669-19-2 2-苄基丙烯酸 | CAS号3516-95-8 2'-羟基-3-苯基苯丙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号3558-60-9 甲基苯乙基醚

反式肉桂醛置于三(2,4,6-三甲氧基苯基)磷 三甲基氰硅烷,盐酸体系中,用 乙腈,乙醚 作为反应溶剂,化学反应 6.5H,以90%的收率获得产物3-苯基丙酸
参考文献:三(2,4,6-三甲氧基苯基)膦:α,β-不饱和醛转化为饱和羧酸衍生物的碱催化剂
标题:三(2,4,6-三甲氧基苯基)膦:α,β-不饱和醛转化为饱和羧酸衍生物的碱催化剂
摘要:我们专注于有机合成中三(2,4,6-三甲氧基苯基)膦(ttmpp)的碱性.为了扩展 Ttmpp 的效用,我们研究了在 Ttmpp 存在下 α,β-不饱和醛与三甲基甲硅烷基氰化物的反应.此外,为了阐明 Ttmpp 的基本特征,我们测量了 Ttmpp 和相关化合物的 31 P NMR.首先,肉桂醛与氰化三甲基甲硅烷在催化量的 Ttmpp 存在下反应,在用 1M Hcl 水解后得到相应的饱和羧酸.用醇或胺代替1M Hcl处理反应混合物,分别得到相应的饱和酯和酰胺.对反应机理的研究表明,反应通过α的甲硅烷基氰化进行的,
DOI:10.1080/10426500600977296

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.