CAS: 53990-33-3; (S)-2-(((Benzyloxy)Carbonyl)Amino)-2-Phenylacetic Acid

上下游产品

(S)-2-phenylglycine benzyl chloroformate 2-(benzyloxycarbonylamino)-2-phenylacetic acid (S)-ethyll 2-(benzyloxycarbonylamino)-2-phenylacetateZ-PhGly-OSu Z-Phg-Ala-OMe Z-Phg-F -L-phenylalanine 2-propenyl esterN-(phenylmethoxy)carbonyl-L-phenylalanine 2-propenyl ester

2-氨基-2-苯基乙酸置于n-甲基吗啉,乙醇,4 A Molecular Sieve体系中,用 四氢呋喃,乙醚 作为反应溶剂,化学反应 16.0H,反应生成 Cbz-L-苯甘氨酸
参考文献:通过金鸡纳生物碱催化的氨基甲酸酯保护的α-氨基酸n-羧基酸酐的动力学拆分,α-氨基酸的不对称合成.
标题:通过金鸡纳生物碱催化的氨基甲酸酯保护的α-氨基酸n-羧基酸酐的动力学拆分,α-氨基酸的不对称合成.
摘要:
DOI:10.1021/ja011936Q

专利信息

专利号:US-4271172-A
优先权日:1979-06-25
标 题 :6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, antibacterial compositions thereof and method of use thereof
发明人：RODRIGUEZ LUDOVIC; LECLERCQ JACQUES; YKMAN PIERRE; COSSEMENT ERIC
权利人:UCB SA
摘要:6-Amino-spiro[penam-2,4'-piperidine]-3-carboxylic acids, salts and esters thereof of the formula ##STR1## wherein R 1 is hydrogen, benzyl or an alkali metal or ammonium ion and R 2 is methyl, phenyl or benzyl and process for preparing the same. n These compounds are useful as intermediates in the synthesis of a new group of antibiotics having properties similar to penicillins, besides own antibiotic activity with a broad antibacterial spectrum. Therefore, they are useful as antibacterials agents and as therapeutic agents for humans and for animals in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

专利号:US-9822116-B2
优先权日:2008-09-05
标 题:Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
发明人：WU GEORGE G; WERNE GERALD; FU XIAOYONG; ORR ROBERT K; CHEN FRANK XING; CUI JIAN; SPRAGUE VICTORIA M; ZHANG FUCHENG; XIE JI; ZENG LIANSHENG; CASTELLANOS LOUIS PETER; CHEN YUYIN; POIRIER MARC; MERGELSBERG INGRID
权利人:OPKO HEALTH INC
摘要:This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

专利号:US-6534627-B1
优先权日:1989-10-23
标题:Synthesis and use of amino acid fluorides as peptide coupling reagents
发明人：CARPINO LOUIS A; EL-FAHAM AYMAN AHMED
权利人:RES CORP TECHNOLOGIES INC
摘要:The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: n or the acid fluoride salts thereof wherein n BLK is an N-amino protecting group; n AA is an amino acid residue; and n X is absent or a protecting group. n The amino acid fluoride is useful as a coupling agent in peptide synthesis.

专利号:US-6486350-B1
优先权日:1998-09-30
标 题:Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
发明人：AUDIA JAMES E; HYSLOP PAUL A; NISSEN JEFFREY S; THOMPSON RICHARD C; TUNG JAY S; TANNER LAURA I
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are biological reagents which comprise compounds that inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of beta-amyloid peptide.

专利号:US-2014031549-A1
优先权日:2008-09-05
标题:Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds

专利号:US-2016145256-A1
优先权日:2008-09-05
标题:Process and intermediates for the synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds