CAS: 627-45-2; N-Ethylformamide

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N,N-二乙基甲酰胺置于microsomal P450体系中,用 水 作为反应溶剂,化学反应生成 N-甲酰乙胺
参考文献:Microsomal Oxidation Of N,N-Diethylformamide And Its Effect On P450-Dependent Monooxygenases In Rat Liver
标题:Microsomal Oxidation Of N,N-Diethylformamide And Its Effect On P450-Dependent Monooxygenases In Rat Liver
摘要:N,N-Diethylformamide (Def) Is A Hepatotoxic Polar Solvent In Which Metabolism Has Not Been Investigated. In This Study We Examined The Following: (A) The Oxidative Metabolism Of Def Using Both Liver Microsomes From Rats Pretreated With Selected P450 Inducers And Purified P450 Enzyme (2B1,2E1,2C11); And (B) The Effect Of Administration Of Def And Its Metabolite,The Monoethylformamide (Mef),On Induction Andlor Inhibition Of The P450 Isoforms In Rats. Def Was Deethylated By Microsomal P450-Dependent Oxidation Forming Acetaldehyde And Mef According To Michaelis-Menten Kinetic Parameters. Microsomes From Rats Pretreated With Acetone And Pyrazole (Selective P4502E1 Inducers) Or Rats Pretreated With Dexamethasone And 200 Mg/kg Def Mere Able To Deethylate Def In A Biphasic Manner,Showing A Low K-M Component With A V-Max Of About 0.2 Nmol/(Min . Mg Of Protein) And A K-M Between 70 Mu M And 250 Mu M. The Low K-M Component Was Not Present In Control Microsomes Or In Microsomes From Rats Treated With Phenobarbital,Beta-Naphthoflavone,Or Clofibrate,Where Linear Kinetics Were Observed. The Use Of Purified P4502E1 And 2C11 In A Reconstituted System Showed That 2E1,Which Oxidized Def With A V-Max Of 4.5 Nmol/(Min . Nmol Of P450) And A K-M Of 0.7 Mm,Can Partially Account For The Low K-M Def Deethylase,Whereas 2C11,Which Oxidized Def With A V-Max Of 4.8 Nmol/(Min . Nmol Of P450) And A K-M Of 17 Mm,Might Be The High K-M Deethylase. The Purified 2B1 Was Barely Able To Deethylate Def. A Confirmation Of The Role Of 2E1 In Def Metabolism Was Obtained By Using Various Selective Inhibitors Of P450 Isoforms And Immunoprecipitation Experiments With Anti P4502E1 Igg. The Low K-M Component Of Def Deethylation In Acetone-Or Pyrazole-Induced Microsomes Was Strongly Inhibited (Similar To 90%) By Diethyldithiocarbamate,4-Methyipyrazole,And Anti-2E1 Igg,But In 200 Mg/kg Def-Induced Microsomes The Inhibition Was Partial,Suggesting That Other P450(S) May Be Involved. Administration Of Def 200 Mg/kg Ip For 4 Days Induced Hepatic Microsomal P4502E1-Dependent Aniline Hydroxylase,P4502B1/2-Linked Pentoxyresorufin O-Depentylase,16 Beta-Testosterone Hydroxylase P4503A1/2-Associated Erythromycin N-Demethylase,And 6 Beta-Testosterone Hydroxylase. Alternatively,The Same Dose Regimen Of Mef Induced Only The Aniline Hydroxylase And Depressed The 3A1/2-Linked Activities. Immunoblot Experiments Verified These Data. These Findings Indicate That Def,At Low Concentrations,Is Predominantly Oxidized By P4502E1 And That This Enzyme May Be Induced In Rodents By Repeated Mef Or Def Treatment,Thereby Increasing Their Own Metabolism And Potentially Their Cytotoxicity Through The Formation Of Ethyl Isocyanate.
DOI:10.1021/tx950201U

专利信息

专利号:US-10364220-B2
优先权日:2012-12-21
标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
发明人：SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-10696622-B2
优先权日:2016-08-29
标题 :Synthesis of N-vinyl carboxylic acid amides
发明人：DUMOLEIJN KIM; MOONEN KRISTOF; Henricot Alexis; Han Cai Xing Simon
权利人:TAMINCO BVBA; EASTMAN CHEM CO
摘要:Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.

专利号:US-9126896-B2
优先权日:2012-06-01
标题:Synthesis of diamido gellants by using Dane salts of amino acids
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group; R 3 represents a C 1 -C 4 alkyl group; R 4 represents a hydrogen atom, or a C 1 -C 4 alkyl group; R 5 represents a C 1 -C 4 alkyl group; and X represents an alkali metal.

专利号:US-6603070-B2
优先权日:2000-07-21
标题 :Convergent synthesis of multiporphyrin light-harvesting rods
发明人：LINDSEY JONATHAN S; LOEWE ROBERT S
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.

专利号:US-9126897-B2
优先权日:2012-06-01
标 题 :Synthesis of diamido gellants by using amino acid N-carboxyanhydrides
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a N-carboxyanhydride according to formula II and a N-carboxy-anhydride according to formula III with a diamine according to formula IV and b) adding an acid to the reaction to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; and R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group.