CAS: 7697-23-6; 2-Fluoro-4-Methylbenzoic Acid

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CAS号352-70-5 3-氟甲苯 | CAS号865-47-4 叔丁醇钾 | CAS号124-38-9 二氧化碳 | CAS号452-74-4 3-氟-4-溴甲苯 | CAS号5326-34-1 4-溴-3-硝基甲苯 | CAS号53078-85-6 2-溴-5-甲基苯胺 | CAS号612-45-3 2-Nitro-p-aceto... | CAS号89-62-3 4-甲基-2-硝基苯胺 | CAS号696-01-5 2-氟对二甲苯 | CAS号95-78-3 2,5-二甲基苯胺 | CAS号74733-29-2 2-氟-4-甲基苯甲酸甲酯 | CAS号753924-40-2 2-氟-4-甲基-5-硝基苯甲酸 | CAS号85070-58-2 2-氟-4-甲酰基苯甲酸甲酯 | CAS号59189-98-9 2-氟-4-甲基苯甲酰氯 | CAS号604000-97-7 2-氟-4-甲酰基苯甲酸

4-甲基-2-硝基-N-乙酰基苯胺置于盐酸,氟硼酸钠,溴乙烷,Claisen'S Base,硫酸,铁粉,Magnesium,溶剂黄146,Sodium Nitrite体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,反应生成 2-氟-4-甲基苯甲酸
参考文献:含氟的4-甲氧基甲基苄基高氯酸盐的合成及其杀虫活性
标题:含氟的4-甲氧基甲基苄基高氯酸盐的合成及其杀虫活性
摘要:为了研究含氟的4-甲氧基甲基苄基高氯酸酯的氟原子位置与杀虫活性之间的关系,合成了2-和3-氟-4-甲氧基甲基苄基(+/-)-顺式-高氯菊酯.测试了它们的杀虫活性,并讨论了标题化合物的氟效应.
DOI:10.1016/s0022-1139(02)00148-3

专利信息

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-7169955-B2
优先权日:2000-02-04
标 题 :Perfluoroisopropylbenzene derivative
发明人：ONISHI MASANOBU; IKEDA KENICHI; SHIMAOKA TAKASHI; YOSHIDA MASANORI
权利人:NIHON NOHYAKU CO LTD
摘要:Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: n nwherein X 1 is H, halogen, formyl, optionally halogenated (C 1 –C 6 ) alkyl, (C 1 –C 6 ) alkylthio, or the like; X 2 is H, halogen, formyl, hydroxyl, (C 1 –C 6 ) alkyl, —C(â•?O)—R 1 (wherein R 1 is H, halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 2 R 3 , with R 2 and R 3 being each H, C 1-6 alkyl, or the like), or the like; X 3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(â•?O)—R 1 , —SO 2 —R 4 (wherein R 4 is halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 5 R 6 , with R 5 and R 6 being each H or (C 1 –C 6 ) alkyl), or the like; and X 4 is H, halogen, (C 1 –C 6 ) alkyl, or (C 1 –C 6 ) alkoxy, with publicly known compounds beingexcepted.

专利号:WO-2014056464-A1
优先权日:2012-10-12
标 题:A new production method and new intermediates of synthesis of elvitegravir

专利号:CN-102633739-A
优先权日:2012-03-22
标 题:Synthesis of 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]thiazole

专利号:CN-102633739-B
优先权日:2012-03-22
标题:Synthesis of 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]thiazole

专利号:CN-109608441-A
优先权日:2018-12-26
标题:A kind of synthesis process of ASK1 inhibitor