CAS: 111-45-5; 2-(Allyloxy)Ethanol

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CAS号107-21-1 乙二醇 | CAS号106-95-6 烯丙基溴 | CAS号3973-18-0 丙炔醇乙氧基化合物 | CAS号107-05-1 氯丙烯 | CAS号15022-08-9 碳酸二烯丙酯 | CAS号821-09-0 4-戊烯-1-醇 | CAS号75-21-8 环氧乙烷 | CAS号107-18-6 烯丙醇 | CAS号3984-22-3 2-乙烯基-1,3-二氧戊环 | CAS号107-07-3 2-氯乙醇 | CAS号441307-02-4 2,2'-(((1,1,3,3... | CAS号188650-07-9 2-aminobenzoic ... | CAS号107-21-1 乙二醇 | CAS号26150-05-0 2-[2-(2-prop-2-... | CAS号24628-30-6 [2-(烯丙氧基)]乙氧基三甲基硅烷 | CAS号15424-04-1 3-(2-溴乙氧基)-丙烯 | CAS号3917-15-5 烯丙基乙烯基醚 | CAS号15075-50-0 二甘醇单烯丙基醚 | CAS号2568-96-9 2-Ethyl-1,3-dio... | CAS号64818-36-6 hex-5-en-1-ol,m...

2-乙烯基-1,3-二氧戊环置于lithium Aluminium Tetrahydride,三氯化铝体系中,用 乙醚 用作溶剂,化学反应生成烯丙基羟乙基醚
参考文献:杂原子取代的甲基基团和连接到 1,3-二氧戊环的 C-2 上的乙烯基基团 (Cr2=cr-) 对 Alh2Cl,Alh3 或 Lialh4 对 1,3-二氧戊环氢解的难易和方向的影响
标题:杂原子取代的甲基基团和连接到 1,3-二氧戊环的 C-2 上的乙烯基基团 (Cr2=cr-) 对 Alh2Cl,Alh3 或 Lialh4 对 1,3-二氧戊环氢解的难易和方向的影响
摘要:2-甲基-1,3-二氧戊环的甲基上的杂原子取代基阻碍了 2-取代的 1,3-二氧戊环的醚溶液的 Alh2Cl 的氢解速率.杂原子在降低氢解容易度方面的有效性是 H < S < O < Br < Nr2.这种延迟被认为是由于杂原子的电负性和/或一些 Alh2Cl 与杂原子的配位引起的过渡态不稳定导致中间氧碳离子.Alh2Cl 或 Alh3 在室温下乙醚中将 2-乙烯基-或 2-[烷基(或芳基)取代的乙烯基]-1,3-二氧戊环还原为仅 β,γ-不饱和烷基 β-羟乙基醚,预期产物是氢阴离子加成到 C-2 1,3-二氧戊环.
Doi:10.1139/v71-422

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-5258531-A
优先权日:1989-12-18
标题:Process for the direct synthesis of organotin compounds and their use
发明人：MALGUZZI ROMUALDO; SANDRI MAURIZIO; ROSENTHAL MICHAEL; PUERZER ALBERT W
权利人:BAERLOCHER GMBH
摘要:The invention relates to a process for the direct synthesis of organotin compounds of the formula n n R.sub.n SnCl.sub.4-n n n wherein n n=1-4, and, n R=a linear or branched or cycloaliphatic alkyl having 4-18 C atoms, n by reacting metallic tin with alkyl chlorides, characterized in that the reaction is carried out in the presence of amines of the general formula n A) R 1 a N [(CH 2 CH 2 O) m CH 2 CH 2 OR 2 ] 3-a n and/or ammonium chlorides of the formula n B) R 1 b N [(CH 2 CH 2 O) m CH 2 CH 2 OR 2 ] 4-b Cl n wherein n a=0, 1 or 2; n b=0, 1, 2 or 3; n R 1 =linear or branched or cycloaliphatic alkyl having 2 to 24 C atoms, aryl, alkyl aryl or substituted aryl and, if a=2, or b=2 or 3, the R 1 groups may be the same or different; n R 2 =H, linear or branched alkyl having 1 to 20 C. atoms, aryl, substituted aryl or alkyl aryl; and n m=1-20.

专利号:US-4581416-A
优先权日:1981-01-19
标题 :Process for the synthesis of tertiary phosphine oxides and sulfides, and new tertiary phosphine oxides and sulfides
发明人：BERGERET WILFRID; BOILEAU SYLVIE; GAUTIER JEAN-CLAUDE; RAYNAL SERGE
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to processes for the synthesis of tertiary phosphine oxides and sulfides. The process according to the invention consists, in a first step, of reacting a secondary phosphine oxide or sulfide with an optionally activated alkali metal amide, and, in a second step, of reacting the mixture obtained in the first step with an organic halide containing at least one halogenophenyl radical or one halogenomethyl group. Tertiary phosphine oxides and sulfides are complexing agents of high stability.

专利号:US-4365094-A
优先权日:1979-12-28
标 题 :Process for the synthesis of tertiary phosphine oxides, and new tertiary phosphine oxides
发明人：BOILEAU SYLVIE L; N GUYEN THANH-DUNG; GAUTIER JEAN-CLAUDE C
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to the synthesis of tertiary phosphine oxides and also to certain tertiary phosphine oxides. According to the invention, an organic phase containing a halogenomethyl derivative, a secondary phosphine oxide and a phase transfer catalyst in an organic medium is reacted with an aqueous phase containing an inorganic base. The halogenomethyl derivative can be a micromolecule or a macromolecule. The tertiary phosphine oxides are substances which are useful, in particular, in fireproofing, in hydrometallurgy and in the field of plant health.

专利号:US-6166237-A
优先权日:1999-08-13
标题:Removal of dissolved silicates from alcohol-silicon direct synthesis solvents
发明人：SIMANDAN TIBERIU LADISLAU; MENDICINO FRANK D
权利人:CROMPTON CORP
摘要:Dissolved silanes, silicones and silicates from solvents used in the slurry phase Direct Synthesis of alkoxysilanes are removed by adding a compatabilizing agent and water to generate filterable precipitates and reusable solvent. The solvents are thereby remediated and made suitable for reuse in Direct Synthesis processes. Foaming is reduced with the remediated solvent and silicon conversion rates are higher. The precipitates are easily filtered and retain negligible quantities of solvent.

专利号:US-9937556-B2
优先权日:2011-11-15
标题 :Templated synthesis of metal nanorods in silica nanotubes
发明人：YIN YADONG; GAO CHUANBO
权利人:UNIV CALIFORNIA
摘要:A method of preparing a metal nanorod. The method includes seeding a metal nanoparticle within the lumen of a nanotube, and growing a metal nanorod from the seeded metal nanoparticle to form a metal nanorod-nanotube composite. In some cases, the nanotube includes metal binding ligands attached to the inner surface. Growing of the metal nanorod includes incubating the seeded nanotube in a solution that includes: a metal source for the metal in the metal nanorod, the metal source including an ion of the metal; a coordinating ligand that forms a stable complex with the metal ion; a reducing agent for reducing the metal ion, and a capping agent that stabilizes atomic monomers of the metal. Compositions derived from the method are also provided.