专利号:WO-2021019558-A1 优先权日:2019-07-30 标题 :An efficient method for synthesis of 5-(3-pyridyl)-2,2'-bithiophene(sensitizer) 发明人:DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT 权利人:FERMENTA BIOTECH LTD 摘要:The present invention discloses an efficient process for synthesis of photosensitizer, 5-(3-pyridyl)-2,2'-bithiophene in high yield and purity.
专利号:US-2025129021-A1 优先权日:2023-09-19 标 题:Small molecule protein synthesis modulators 发明人:GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE 权利人:INTERDICT BIO INC 摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.
专利号:US-5565573-A 优先权日:1993-11-12 标 题:Synthesis of epibatidine and analogs thereof 发明人:LAROCK RICHARD C 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention provides a method to prepare epibatidine or an analog thereof comprising reacting a bicyclic olefin or diene, such as an azanorbornene, with an aryl or heteroaryl halide or triflate in the presence of a catalytic amount of Pd(O) and a formate salt.
专利号:WO-2021062168-A1 优先权日:2019-09-25 标 题 :Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment 发明人:EDINGER AIMEE; HANESSIAN STEPHEN 权利人:UNIV CALIFORNIA; UNIV MONTREAL 摘要:Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.
专利号:US-5183929-A 优先权日:1988-01-14 标 题:Method for production of T-butyl 3-oxobutyrates and their use 发明人:NAITO KENZO; ISHIBASHI YUKIO; SHINBO HARUO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:Disclosed are an advantageous method of industrial production of tert-butyl 3-oxobutylate, which is a useful intermediate for synthesis, characterized by reacting tert-butyl alcohol with diketene in the presence of 4-(tertiary amino) pyridine, and an industrially advantageous method of producing cephalosporin compounds or pharmaceutically acceptable salts thereof, using tert-butyl 3-oxobutylate as an intermediate.
专利号:US-4370507-A 优先权日:1980-09-11 标题:Ethanol from methanol and synthesis gas 发明人:HARGIS DUANE C; DUBECK MICHAEL 权利人:ETHYL CORP 摘要:A process for selectively preparing ethanol by contacting methanol, hydrogen and carbon monoxide with a solid catalyst comprising rhodium and iron in the reduced state deposited on a support of alumina impregnated with a promoter amount of a heterocyclic amine at reaction conditions correlated so as to favor the formation of a substantial proportion of ethanol.
[参考文献]: Alina K Feldman, Et Al. One-Pot Synthesis Of 1,4-Disubstituted 1,2,3-Triazoles From In Situ Generated Azides. Org Lett. 2004 Oct 28;6(22):3897-9.
合成参考文献
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