CAS: 115929-59-4; 2-Bromo-4-Methoxy-6-Nitrophenol

相似化合物

206872-01-7 55034-12-3 1823901-35-4

上下游产品

CAS号1568-70-3 4-甲氧基-2-硝基酚 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号70563-58-5 除莠霉素A | CAS号524684-52-4 普林贝瑞 | CAS号206872-01-7 2-氨基-6-溴-4-甲氧基苯酚 | CAS号55034-12-3 1-bromo-2,5-dim...

4-甲氧基-2-硝基酚置于溴,溶剂黄146,Potassium Bromide体系中,用 水 用作溶剂,化学反应 16.0H,以89%的收率获得2-溴-4-甲氧基-6-硝基苯酚
参考文献:作为 Ido1 抑制剂的 Exiguamine A 类似物的设计,合成和生物学评价
标题:作为 Ido1 抑制剂的 Exiguamine A 类似物的设计,合成和生物学评价
摘要:通过 15 个步骤设计和合成了一系列 Exiguamine A 类似物.测试了它们对 Ido1 的抑制活性,并研究了构效关系.大多数化合物表现出有效的 Ido1 抑制活性,Ic 50值为 10-7-10-8 M.化合物21F是最有效的 Ido1 抑制剂,Ic 50值为 65.3 Nm,与阳性对照药物 Epacadostat 相当(Ic 50 = 46 Nm).此外,化合物21F对 Ido1 显示出比色氨酸 2,3-双加氧酶 (Tdo) 更高的选择性,并且在其有效浓度下没有细胞毒性,这使其有理由进一步优化和评估.
Doi:10.1016/j.Ejmech.2021.113631

专利信息

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.