CAS: 18979-60-7; 4-Propylbenzene-1,3-Diol

该化合物是一种二氢氧替代芳香化合物,在苯环的4位置上有一个丙基化合物组,这种结构具有独特的化学特性,在有机合成中,特别是在生产药品,农用化学品和特殊聚合物方面,具有作为中间体的价值.它的苯基氢氧化物组会提高电益替代和氧化反应的再活性,而丙基亚基成分会影响溶解性和亲脂性.该化合物常常用于需要控制芳香系统功能化的研究应用中.高纯度能确保合成途径的性能.由于对光和空气氧化的潜在敏感性,建议适当处理.

结构式图片

上下游产品

CAS号5792-36-9 2',4'-二羟基苯丙酮 | CAS号108-46-3 间苯二酚 | CAS号2999-19-1 2,4-dipropionyl... | CAS号1616-52-0 4-prop-2-enylbe... | CAS号1616-51-9 3-prop-2-enoxyphenol | CAS号54494-87-0 resorcinol, sod... | CAS号7647-01-0 盐酸 | CAS号64-17-5 乙醇 | CAS号85131-64-2 1-(5-chloro-2,4... | CAS号36680-47-4 2,4-dimethoxy-1... | CAS号85681-95-4 5-amino-2-propy... | CAS号6298-86-8 1,3-Benzenediol... | CAS号63411-87-0 1-(2,4-二羟基-5-丙基...

合成工艺路线路线简述

    2,4-Dipropionyl-Resorcinol置于盐酸,Amalgamated Zinc体系中,化学反应生成4-丙基间苯二酚
    参考文献:Mavrodin; Herescu,1941,Vol. 6,P. 3,17
    标题:Mavrodin; Herescu,1941,Vol. 6,P. 3,17

    海关参考信息

    专利信息


    专利号:US-11746364-B2
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
    发明人:PLUSKAL TOMÃ?S; Weng jing-ke
    权利人:WHITEHEAD INST BIOMEDICAL RES
    摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

    专利号:US-2006129002-A1
    优先权日:2004-12-15
    标 题:Process for the synthesis of alkylresorcinols
    发明人:WASSMANN-WILKEN SUZANNE; SCHMIDT HANS-JURGEN; WILKEN JORG; KANSCHIK-CONRADSEN ANDREAS
    权利人:HONEYWELL INT INC
    摘要:The invention provides a process for the production of 4-(C 2 -C 16 )alkylresorcinol. 4-(C 2 -C 16 )alkylresorcinol is produced by reacting resorcinol with a (C 2 -C 16 )alkyloic acid in the presence of a zinc chloride catalyst to produce an intermediate comprising a 4-(C 2 -C 16 )acylresorcinol and zinc ions. Then the intermediate is adjusted such that the zinc ion content is from about 0.1 to about 150 parts per million based on the weight of the intermediate to form an adjusted intermediate. Then the produced 4-(C 2 -C 16 )acylresorcinol is hydrogenated in the presence of the zinc ions and a base metal hydrogenation catalyst to produce a crude product comprising 4-(C 2 -C 16 )alkylresorcinol, which may thereafter be isolated.

    专利号:US-7276571-B2
    优先权日:2005-06-29
    标题:Process for making phenylene dioxydiacetic acid and use thereof
    发明人:DURAIRAJ RAJ B; TACKIE MICHAEL N
    权利人:DURAIRAJ RAJ B; TACKIE MICHAEL N
    摘要:A process for making phenylene dioxydiacetic acid comprises (a) contacting a dihydroxybenzene under reaction conditions with a salt of haloacetic acid in a solution without adding a haloacetic acid to produce a salt of phenylene dioxydiacetic acid; and (b) optionally converting the salt of phenylene dioxydiacetic acid to free phenylene dioxydiacetic acid. In some embodiments, 1,3-phenylene dioxydiacetic acid (RDOA) is made by reacting resorcinol with sodium chloroacetic acid in a reaction mixture with a pH in the range of about 7 to about 11 and at a temperature from about 70° C. to 105° C. By adjusting the reactions conditions, a relatively high yield of 1,3-phenylene dioxydiacetic acid (i.e., greater than 80%) is obtained. The purified acid can be used in the synthesis of polyester, such as polyethylene terephthalate.

    专利号:EP-1836163-B1
    优先权日:2004-12-23
    标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
    发明人:BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
    权利人:NOVARTIS AG
    摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

    专利号:US-9782363-B2
    优先权日:2012-10-12
    标 题 :Anti-virulance compositions and methods
    发明人:SHOHAM MENACHEM; VISWANATHAN RAJESH; YU GUANPING
    权利人:UNIV CASE WESTERN RESERVE
    摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.

    专利号:US-11739354-B2
    优先权日:2018-01-17
    标 题 :Enzymatic synthesis of kavalactones and flavokavains
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    合成参考文献


    参考文献:10.1007/978-1-4020-9787-4_11
    摘要:Martin R. Compounds Derived from Halogenoacetic Acids. 2011. In: Aromatic Hydroxyketones: Preparation and Physical Properties.
    参考文献:10.1007/s42535-024-00830-6
    摘要:Bennacer A, Sahir-Halouane F, Aitslimane-Aitkaki S, Tihar-Benzina F, Oukali Z, Oliveira IV, Rahmouni N, Aissaoui M, Mohankumar R. Exploring the antifungal properties of tannin extracts from Olea europaea var. rougette leaves against Aspergillus spp. Vegetos. 2024 Mar 08;38(1):353–63. doi: 10.1007/s42535-024-00830-6.
    参考文献:10.1007/978-3-031-70499-4_14
    摘要:Khan I, Wongwas S, Yousaf S. Review of Formulation Strategies to Enhance the Sun Protection Factor Values. 2024 Dec 29. In: Micro and Nanomanufacturing Volume II.
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