CAS: 20925-27-3; 4-Amino-2-Chlorobenzonitrile

上下游产品

2-氯-4-硝基苯腈 2-Chloro-4-Nitrobenzonitrile 28163-00-0
N-(3-Chloro-4-Cyanophenyl)Acetamide 22304-33-2
2,4-二氯苯腈 2,4-Dichlorobenzylnitrile 6574-98-7
对氨基苯腈 4-Aminobenzonitrile 873-74-5

4-溴-2-氯苯甲腈置于tris-(Dibenzylideneacetone)Dipalladium(0) Polystyrene Rink Amine Resin,R-(+)-1,1'-联萘-2,2'-双二苯膦,Sodium T-Butanolate体系中,用 1,4-二氧六环,叔丁醇,二氯甲烷 用作溶剂,化学反应 20.75H,反应生成2-氯-4-氨基苯腈
参考文献:固体载体上钯催化的芳基卤化物的胺化反应.
标题:固体载体上钯催化的芳基卤化物的胺化反应.
摘要:[反应:见正文]描述了使用rink树脂作为氮源进行pd(0)催化的芳基卤化物胺化反应的第一个实例.发现pd(2)dba(3)/ Binap / Nao-T-Bu是最有效的催化剂/碱体系,而二恶烷和叔丁醇的溶剂混合物显示可以提高对所需单芳基化反应的选择性.用贫电子的芳基卤化物发现中度到非常好的收率和极好的纯度的胺化产物,而富电子的芳基卤化物在这些条件下不能反应.
Doi:10.1021/ol027119S

专利信息

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.

专利号:US-4035350-A
优先权日:1975-01-30
标 题:Process for the preparation of water-soluble azo dyestuffs by reacting an aromatic amine and a coupling component with alkali metal nitrite or alkyl nitrite in the absence of acid
发明人：LANDLER JOSEF; WORFEL ERHARD
权利人:HOECHST AG
摘要:A new and very advantageous Process had been found for the preparation of azo dyestuffs by diazotation and coupling in which the synthesis is carried out without the hitherto usual addition of an acid, with the proviso that at least one of the diazo and coupling components contains at least one acid group. Besides the saving of reaction material and subsequently of alkali for neutralization of the reaction medium and isolation of the dyestuff, highly concentrated solutions of the dyestuff and salt-free or practically salt-free dyestuffs can be obtained, and waste-water is no longer charged with big amounts of salts.

专利号:US-2008139558-A1
优先权日:2006-02-24
标题 :Quinolones useful as inducible nitric oxide synthase inhibitors
发明人：SMITH NICHOLAS D; ROPPE JEFFREY R; BONNEFOUS CELINE; PAYNE JOSEPH E; ZHUANG HUI; CHEN XIAOHONG; LINDSTROM ANDREW K; DURON SERGIO G; HASSIG CHRISTIAN A; NOBLE STEWART A
权利人:KALYPSYS INC
摘要:The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.

专利号:CN-116490201-A
优先权日:2020-07-02
标题 :Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use

专利号:WO-2022006548-A1
优先权日:2020-07-02
标题:Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof

专利号:CA-3184396-A1
优先权日:2020-07-02
标 题:Inhibitors of yap/taz-tead oncoproteins, synthesis and use thereof