CAS: 28957-72-4; 8-Benzyl-8-Azabicyclo[3.2.1]Octan-3-One

上下游产品

CAS号542-05-2 1,3-丙酮二羧酸 | CAS号100-46-9 苄胺 | CAS号696-59-3 2,5-二甲氧基四氢呋喃 | CAS号638-37-9 丁二醛 | CAS号3287-99-8 苄胺盐酸盐 | CAS号50893-53-3 1-氯乙基氯甲酸酯 | CAS号100-39-0 溴化苄 | CAS号473-90-5 中草酸 | CAS号532-24-1 托品酮 | CAS号5632-84-8 去甲托品酮 | CAS号423165-07-5 (1R,3s,5S)-3-(3... | CAS号5632-84-8 去甲托品酮 | CAS号376348-70-8 N-叔丁氧羰基-(1S)-3-... | CAS号376348-67-3 N-(8-苄基-8-氮杂双环[... | CAS号423165-13-3 8-苄基-3-外型-(5-异丙... | CAS号185099-67-6 N-叔丁氧羰基-去甲托品酮 | CAS号76272-36-1 外向-8-苄基-8-氮杂双环[... | CAS号76272-35-0 内向-8-苄基-8-氮杂双环[... | CAS号76272-34-9 8-苄基-8-氮杂双环[3.2... | CAS号132234-68-5 N-[(3-exo)-8-氮杂...

托品酮置于potassium Carbonate体系中,用 乙醇,丙酮 用作溶剂,化学反应 1.0H,反应生成N-苄基托品酮
参考文献:高效,两步合成n-取代的降钙素原衍生物
标题:高效,两步合成n-取代的降钙素原衍生物
摘要:我们描述了一种新的策略,用于从肌钙蛋白开始合成n-取代的降钙肌酮衍生物.我们合成的关键步骤是肌钙蛋白的反应性增强,可生成8,8-二甲基-3-氧代-8-氮杂-双环[3.2.1]辛烷碘化物(idabo),是稳定且方便的环庚二烯酮合成等效物.
Doi:10.1016/j.Tetlet.2007.05.110

专利信息

专利号:US-6191272-B1
优先权日:1999-02-20
标题:Process for the preparation of endo-nortropine using 8-benzyl-nortropan-3-one perchlorate as the intermediate, as well as the latter salt
发明人：SACHSE ROLF; SCHAUPP ALBERT
权利人:ROBERT PFLEGER CHEM FAB GMBH D
摘要:The invention relates to a process for the preparation of endo-nortropine using 8-benzyl-nortropan-3-one perchlorate, as well as the latter product. Endo-nortropine is the key product for the production of important azonia-spironortropanol esters, which are used as pharmaceuticals, particularly spasmolytics. There are three different synthesis methods for the preparation of said intermediate, which lead to different disadvantages. These problems are obviated by the present invention through the two-stage treatment of 8-benzyl-nortropan-3-one perchlorate with catalytically activated hydrogen, the starting product initially being prehydrogenated in aqueous suspension and at atmospheric pressure and ambient pressure with a palladium catalyst, at the end of the reaction the catalyst is recovered by filtration, the filtrate is passed over an anion exchanger and the now alkaline reacting solution is rendered turbulent at 1000 to 1500 r.p.m. with hydrogen activated by Raney nickel at atmospheric pressure and ambient temperature. This new synthesis method using the novel perchlorate salt as an intermediate is extremely economic and environmentally friendly and supplies substantially completely stereoselectively the desired endo-form of nortropine.

专利号:US-2012172350-A1
优先权日:2009-09-11
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:WO-2022241188-A1
优先权日:2021-05-14
标题 :Enantioselective synthesis of aminotropane compound
发明人：CONZA MATTEO; HAIM CYRIL
权利人:THERAVANCE BIOPHARMA R&D IP LLC
摘要:The present disclosure provides processes for preparing fert-butyl (1 R,3s,5S)-3- amino-8-azabicyclo[3.2.1]octane-8-carboxylate or a salt thereof. The present disclosure also provides enantioselective processes for preparing exo-aminotropane derivatives from tropinone oximes.

专利号:RU-2469035-C2
优先权日:2007-07-20
标题 :METHOD OF PRODUCING INTERMEDIATE PRODUCT FOR SYNTHESIS OF mu OPIOID RECEPTOR ANTAGONISTS

专利号:WO-2014173375-A1
优先权日:2013-04-26
标题 :A process for the synthesis of maraviroc

专利号:US-6245773-B1
优先权日:1996-05-16
标题:5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
发明人：WONG WAI C; LAGU BHARAT; NAGARATHNAM DHANAPALAN; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.