CAS: 4175-76-2; 2,4-Dichlorothiazole

该化合物是一个多用途的杂交循环化合物,其2和4个位置用氯原子取代了三硝基岩芯,具有高度的回活动性,使其成为有机合成的宝贵中间体,特别是制药,农用化学品和特殊化学品.电排氯组增强了其在核循环替代反应中的效用,使得能够引入多种功能组.在标准条件下的稳定性和与各种反应条件的兼容性进一步有助于其广泛适用性.该复合体在构建复杂的分子框架方面特别有用,在合成路径上提供了效率和选择性.适当的处理因其潜在的回活动性和毒性而值得注意.

英文名称2,4-Dichlorothiazole
中文名称2,4-二氯噻唑
IUPAC名称2,4-dichlorothiazole
其它别名2,4-二氯-1,3-噻唑; 2,4-Dichloro-Thiazole
CAS编号4175-76-2
MFCD编号:MFCD08691358
EINECS号:679-703-5
FDA UNII编号:NE9ZB6F5GQ
分子式:C3HCl2NS
分子量:154.01
产品CID: 1431518
产品分类有机原料→分子砌块→芳杂环类化合物→噻唑类化合物

相似结构搜索
产品信息参考
InChIKey: ICETWLGKJXCIDX-UHFFFAOYSA-N
InChI=1S/C3HCl2NS/c4-2-1-7-3(5)6-2/h1H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi
安全声明26-36
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2,4-Dichlorothiazole 主要起始原料 2,4-Thiazolidinedione
(文献来源)合成步骤主要原料 2,4-Thiazolidinedione

2,4-噻唑烷二酮置于吡啶,三氯氧磷体系中,化学反应 3.0H,以52%的收率获得产物2,4-二氯噻唑
参考文献:二烷氧基联噻唑:头对头聚合物半导体的新构建块
标题:二烷氧基联噻唑:头对头聚合物半导体的新构建块
摘要:由于基于溶液的印刷技术提供的低制造成本,聚合物半导体在有机电子领域受到了极大的关注.为了实现所需的溶解性/加工性和载流子迁移率,聚合物通过战略性地操纵烷基化模式用烃链进行功能化.请注意,传统上一直避免头对头 (Hh) 连接,因为诱导的主链扭转会导致 π-π 重叠和非晶膜微结构不良,从而导致载流子迁移率低.我们在此报告了 Hh 连接的新构件 4,4'-二烷氧基-5,5'-联噻唑 (Btzor) 的合成,以及将其掺入用于高性能有机薄膜晶体管的聚合物中.小的氧范德华半径和分子内s(噻唑基)...o(烷氧基)吸引力促进了具有广泛π共轭,低带隙(1.40-1.63 Ev)和高结晶度的hh大分子结构.与之前报道的 3,3'-二烷氧基-2,2'-联噻吩 (Btor) 相比,Btzor 是一种很有前途的结构单元,因为它具有噻唑几何和电子特性:(A) 用 (噻唑)N 代替 (噻吩)Ch通过消除ch...hc与相邻芳
DOI:10.1021/ja3120532

专利信息

专利号:US-2008280855-A1
优先权日:2005-06-22
标题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:ES-2261696-T3
优先权日:2001-07-31
标题:DERIVATIVES OF HETEROARILHETEROALQUILAMINAS AND ITS USE AS INHIBITORS OF THE SYNTHESIS OF NITRIC OXIDE.

专利号:CN-102060862-A
优先权日:2009-11-16
标题 :Synthesis method of 5,7-dichlorothiazole[4,5-d]pyrimidine

专利号:US-12233062-B2
优先权日:2018-09-26
标题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人：HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.